Selected Quarterly Financial Information (unaudited) (Tables)

12 Months Ended

Dec. 31, 2015

Selected Quarterly Financial Information (unaudited)

Summary of the quarterly results of operations

	2015
	March 31		June 30			September 30			December 31
Collaboration revenue	$	41,678	$	1,597		$	3,448		$	4,782
Research and development expenses		24,557		32,059			40,479			33,917
General and administrative expenses		9,584		11,959			10,412			12,066
Income (loss) from operations		7,537		(42,421	)		(47,443	)		(41,201	)
Net income (loss) attributable to common stockholders	$	6,636	$	(37,131	)	$	(39,573	)	$	(35,649	)
Basic earnings (loss) per common share	$	0.19	$	(1.08	)	$	(1.14	)	$	(1.02	)
Diluted earnings (loss) per common share	$	0.19	$	(1.08	)	$	(1.14	)	$	(1.02	)

	2014
	March 31			June 30			September 30		December 31
Collaboration revenue	$	—		$	—		$	39,575	$	1,684
Research and development expenses		14,377			34,707			17,105		22,196
General and administrative expenses		6,349			7,570			8,812		10,656
Income (loss) from operations		(20,726	)		(42,277	)		13,658		(31,168	)
Net income (loss) attributable to common stockholders	$	(20,682	)	$	(72,990	)	$	8,552	$	(31,652	)
Basic earnings (loss) per common share	$	(0.64	)	$	(2.19	)	$	0.26	$	(0.94	)
Diluted earnings (loss) per common share	$	(0.64	)	$	(2.19	)	$	0.25	$	(0.94	)