Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2015

Summary of Significant Accounting Policies

Schedule of collaboration revenue components

	Years ended December 31,
	2015		2014		2013
License revenue	$	38,083	$	38,373	$	—
Research and development activity revenue		8,378		2,000		—
API transfer revenue		5,020		883		—
Joint operating committee revenue		24		3		—
Total collaboration revenue	$	51,505	$	41,259	$	—

Schedule of share-based compensation expense including expenses related to stock options and RSUs granted to employees and non-employees

	Years ended December 31,
	2015		2014		2013
Research and development	$	16,608	$	7,594	$	2,062
General and administrative		8,152		5,446		809
Total	$	24,760	$	13,040	$	2,871