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Product and Technology Agreements (Details) (USD $)
3 Months Ended 12 Months Ended 84 Months Ended 0 Months Ended 12 Months Ended 12 Months Ended 0 Months Ended 0 Months Ended
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 30, 2012
Sep. 30, 2012
Jun. 30, 2012
Mar. 31, 2012
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2007
Dec. 31, 2013
Dec. 31, 2012
Junior Series A Preferred Stock
Dec. 31, 2012
Series A-1 Preferred Stock
Dec. 31, 2012
Series B-1 Preferred Stock
Aug. 09, 2007
Divestiture Agreement
Junior Series A Preferred Stock
Jul. 27, 2007
Divestiture Agreement
Transferor
Jul. 27, 2007
Supply Agreement
Supplier
Dec. 31, 2010
Supply Agreement
Supplier
Dec. 31, 2008
License Agreements
Series A-1 Preferred Stock
Jan. 04, 2008
License Agreements
Series A-1 Preferred Stock
Aug. 09, 2007
License Agreements
Series A-1 Preferred Stock
Dec. 31, 2013
License Agreements
PDGF Licensed Products
Dec. 31, 2013
License Agreements
C5 Licensed Product
Dec. 31, 2013
License Agreements
Licensor
Jan. 04, 2008
License Agreements
Licensor
Series A-1 Preferred Stock
Aug. 09, 2007
License Agreements
Licensor
Series A-1 Preferred Stock
Sep. 12, 2011
License Agreements
Licensor
Series B-1 Preferred Stock
Product and Technology Agreements                                                          
Upfront payment                                   $ 4,000,000               $ 1,000,000      
Preferred stock issued (in shares)                           3,000,000     3,000,000                        
Share price (in dollars per share)                                 $ 1.00         $ 1.00 $ 1.00       $ 1.00 $ 1.00 $ 1.00
Aggregate payment to supplier                                     300,000                    
Aggregate payment                                       800,000                  
Shares issued                             6,000,000 500,000                     4,000,000 2,000,000 500,000
Research and development expense related to upfront fees                       5,000,000                                  
Research and development expense related to issuance of preferred stock                       5,000,000                                  
Research and development expense $ 15,379,000 $ 11,101,000 $ 4,345,000 $ 2,390,000 $ 1,998,000 $ 1,595,000 $ 1,578,000 $ 1,621,000 $ 33,215,000 $ 6,792,000 $ 13,896,000   $ 108,107,000               $ 4,000,000           $ 4,000,000   $ 500,000
Expiration period of agreements                                               10 years 12 years