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Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2013
Significant Accounting Policies  
Schedule of share-based compensation expense including stock options granted to employees and non-employees

 

 
   Years ended
December 31,		  
 
   2013   2012   2011  
 
   (in thousands)
  

Research and development

   $ 2,062   $ 412   $ 159  

General and administrative

     809     228     89  
               
​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Total

   $ 2,871   $ 640   $ 248  
               
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