Selected Quarterly Financial Information (unaudited)

9 Months Ended

12 Months Ended

Sep. 30, 2013

Dec. 31, 2012

Selected Quarterly Financial Information (unaudited)

Selected Quarterly Financial Information (unaudited)

9. Selected Quarterly Financial Information (unaudited)

        The following is a summary of the quarterly results of operations for 2013 and 2012 (in thousands, except per share amounts):

	2013
	March 31			June 30			September 30
Revenues	$	—		$	—		$	—
Research and development		2,390			4,345			11,101
General and administrative		1,738			3,241			4,166
Loss from operations		(4,128	)		(7,586	)		(15,267	)
Net loss attributable to common shareholders	$	(6,361	)	$	(11,863	)	$	(18,424	)
Basic and diluted earnings per common share	$	(4.33	)	$	(8.07	)	$	(10.26	)

	2012
	March 31			June 30			September 30
Revenues	$	—		$	—		$	—
Research and development		1,621			1,578			1,595
General and administrative		1,388			1,694			2,259
Loss from operations		(3,009	)		(3,272	)		(3,854	)
Net loss attributable to common shareholders	$	(4,765	)	$	(5,326	)	$	(5,928	)
Basic and diluted earnings per common share	$	(3.31	)	$	(3.68	)	$	(4.07	)

16. Selected Quarterly Financial Information (unaudited)

        The following is a summary of the quarterly results of operations for the years ended December 31, 2012 and 2011 (in thousands, except per share amounts):

	2012
	March 31			June 30			September 30			December 31
Revenues	$	—		$	—		$	—		$	—
Research and development		1,621			1,578			1,595			1,998
General and administrative		1,388			1,694			2,259			1,548
Loss from operations		(3,009	)		(3,272	)		(3,854	)		(3,546	)
Net loss attributable to common shareholders	$	(4,765	)	$	(5,326	)	$	(5,928	)	$	(5,606	)
Basic and diluted earnings per common share	$	(3.31	)	$	(3.68	)	$	(4.07	)	$	(3.82	)

	2011
	March 31			June 30			September 30			December 31
Revenues	$	—		$	—		$	—		$	—
Research and development		3,531			3,316			3,627			3,422
General and administrative		1,194			1,396			1,321			1,827
Loss from operations		(4,725	)		(4,712	)		(4,948	)		(5,249	)
Net loss attributable to common shareholders	$	(6,213	)	$	(6,441	)	$	(6,765	)	$	(6,052	)
Basic and diluted earnings per common share	$	(4.56	)	$	(4.65	)	$	(4.81	)	$	(4.27	)