Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Common Stock	Preferred Stock – Series C-2, C-3, Series D, Series E, Series F and Series G	Accumulated Other Comprehensive Gain (Loss)	Additional Paid-in Capital	Accumulated Deficit	Total
Balance at Dec. 31, 2017	$ 14,283	$ 420	$ 98,433	$ 159,255,081	$ (152,174,866)	$ 7,193,351
Balance ,Shares at Dec. 31, 2017	14,282,758	419,585
Stock issued in connection with ATM sale of common stock, net	$ 7,178			21,960,828		21,968,006
Stock issued in connection with ATM sale of common stock, net, Shares	7,177,754
Value of warrants related to convertible note				1,122,355		1,122,355
Beneficial conversion feature related to convertible note				143,431		143,431
Stock issued in connection with warrants exercised	$ 5			26,245		26,250
Stock issued in connection with warrants exercised, Shares	5,000
Stock issued in connection with warrants cashless exercised	$ 250			(250)
Stock issued in connection with warrants cashless exercised, Shares	249,770
Issuance of restricted stock	$ 26			(26)
Issuance of restricted stock, Shares	26,365
Stock issued for payment of deferred fees	$ 25			173,748		173,773
Stock issued for payment of deferred fees, Shares	25,526
Stock issued in connection with stock options exercised	$ 8			11,592		11,600
Stock issued in connection with stock options exercised, Shares	8,000
Stock-based compensation				1,110,632		1,110,632
Cumulative effect of adoption of ASC 606					16,398	16,398
Other comprehensive gain loss			(1,911)			(1,911)
Net loss					(26,829,630)	(26,829,630)
Balance at Dec. 31, 2018	$ 21,775	$ 420	96,522	183,803,636	(178,988,098)	4,934,256
Balance, Shares at Dec. 31, 2018	21,775,173	419,585
Stock issued in connection with ATM sale of common stock, net	$ 1,768			15,232,761		15,234,529
Stock issued in connection with ATM sale of common stock, net, Shares	1,768,012
Stock issued in connection with warrants exercised	$ 1,948			8,672,036		8,673,984
Stock issued in connection with warrants exercised, Shares	1,948,207
Exchange of convertible note for Series G preferred Stock, related party				8,673,509		8,673,509
Exchange of Series C-2, Series D and Series F preferred stock for Series G preferred stock, related party		$ (226)		226
Exchange of Series C-2, Series D and Series F preferred stock for Series G preferred stock, related party, Shares		(225,962)
Issuance of Series G preferred stock, related party		$ 100		(100)
Issuance of Series G preferred stock, related party, Shares		100,000
Stock issued in connection with stock options exercised	$ 38			122,666		122,704
Stock issued in connection with stock options exercised, Shares	38,090
Conversion of Series C-3 non-voting preferred stock to common stock	$ 104	$ (52)		(52)
Conversion of Series C-3 non-voting preferred stock to common stock, Shares	104,000	(52,000)
Issuance of vested restricted stock	$ 25			(25)
Issuance of vested restricted stock, Shares	25,346
Issuance of common stock as a result of reverse stock split rounding	$ 7			(7)
Issuance of common stock as a result of reverse stock split rounding, Shares	6,522
Stock-based compensation				2,439,618		2,439,618
Other comprehensive gain loss			735			735
Net loss					(16,433,074)	(16,433,074)
Balance at Dec. 31, 2019	$ 25,665	$ 242	$ 97,257	$ 218,944,268	$ (195,421,172)	$ 23,646,260
Balance, Shares at Dec. 31, 2019	25,665,350	241,623