<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2015-05-20</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001014739</issuerCik>
        <issuerName>BioScrip, Inc.</issuerName>
        <issuerTradingSymbol>BIOS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001409751</rptOwnerCik>
            <rptOwnerName>Coliseum Capital Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001430708</rptOwnerCik>
            <rptOwnerName>Shackelton Christopher S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001409585</rptOwnerCik>
            <rptOwnerName>Coliseum Capital, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001356974</rptOwnerCik>
            <rptOwnerName>COLISEUM CAPITAL PARTNERS L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001567187</rptOwnerCik>
            <rptOwnerName>Coliseum Capital Partners II, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001454123</rptOwnerCik>
            <rptOwnerName>Gray Adam</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Phantom Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2015-05-20</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>10000</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>10000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Each share of phantom stock is a market-based cash award which is the economic equivalent of one share of the Issuer's common stock, par value $0.0001 per share (the &quot;Common Stock&quot;). Each share of phantom stock is entitled to a cash payment equal to the fair market value of a share of Common Stock as of the vesting date, based on the closing market price of the Common Stock on such date.</footnote>
        <footnote id="F2">The shares of phantom stock vest on the business day immediately preceding the date of the Issuer's 2016 annual meeting of stockholders, provided that Christopher Shackelton (&quot;Shackelton&quot;) continues to serve as a director of the Issuer as of such date. If unvested on the vesting date, the shares of phantom stock expire.</footnote>
        <footnote id="F3">The phantom stock was received by Shackelton in connection with his service as a member of the board of directors of the Issuer. Shackelton has agreed that all equity awards he receives for serving as a director of the Issuer shall be issued to Coliseum Capital Partners, L.P. (&quot;CCP&quot;).</footnote>
        <footnote id="F4">Shackelton and Adam Gray (&quot;Gray&quot;) are managers of and have an ownership interest in each of (a) Coliseum Capital Management, LLC (&quot;CCM&quot;), the investment advisor to and a separate investment advisory account managed by CCM (the &quot;Separate Account&quot;) and (b) Coliseum Capital, LLC (&quot;CC&quot;), the general partner of each of CCP and Coliseum Capital Partners II, L.P. (&quot;CCP2&quot;) and may be deemed to have an indirect pecuniary interest in the shares held by CCP, CCP2, and the Separate Account due to CCM's right to receive performance-related fees from the Separate Account and CC's right to receive performance-related fees from CCP and CCP2. Each of the Reporting Persons disclaims beneficial ownership of these securities except to the extent of that person's pecuniary interest therein.</footnote>
    </footnotes>

    <remarks>Shackelton is a director of the Issuer. As a result, the following persons may be deemed directors by deputization of the Issuer solely for purposes of Section 16 of the Securities Exchange Act of 1934, as amended: Gray, CCM, CC, CCP, and CCP2.</remarks>

    <ownerSignature>
        <signatureName>Coliseum Capital Management, LLC, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Christopher Shackelton</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital, LLC, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital Partners, L.P., By: Coliseum Capital, LLC, its General Partner, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital Partners II, L.P., By: Coliseum Capital, LLC, its General Partner, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Adam Gray</signatureName>
        <signatureDate>2015-05-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
