<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2015-08-21</periodOfReport>

    <dateOfOriginalSubmission>2015-08-24</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001014739</issuerCik>
        <issuerName>BioScrip, Inc.</issuerName>
        <issuerTradingSymbol>BIOS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001409751</rptOwnerCik>
            <rptOwnerName>Coliseum Capital Management, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR SOUTH</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001430708</rptOwnerCik>
            <rptOwnerName>Shackelton Christopher S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR,</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001409585</rptOwnerCik>
            <rptOwnerName>Coliseum Capital, LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR,</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001356974</rptOwnerCik>
            <rptOwnerName>COLISEUM CAPITAL PARTNERS L P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR,</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001567187</rptOwnerCik>
            <rptOwnerName>Coliseum Capital Partners II, L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR,</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001454123</rptOwnerCik>
            <rptOwnerName>Gray Adam</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>METRO CENTER</rptOwnerStreet1>
            <rptOwnerStreet2>1 STATION PLACE, 7TH FLOOR,</rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2015-08-21</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>397900</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.82</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>632907</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.76 to $1.85, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission (the &quot;SEC&quot;), upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.</footnote>
        <footnote id="F2">These securities are held directly by (a) Coliseum Capital Partners, L.P. (&quot;CCP&quot;), an investment limited partnership of which Coliseum Capital, LLC, a Delaware limited liability company (&quot;CC&quot;), is general partner and for which Coliseum Capital Management, LLC, a Delaware limited liability company (&quot;CCM&quot;), serves as investment adviser, (b) Coliseum Capital Partners II, L.P. (&quot;CCP2&quot; and, together with CCP, the &quot;Funds&quot;), an investment limited partnership of which CC is general partner and for which CCM serves as investment adviser, and (c) a separate account investment advisory client of CCM (the &quot;Separate Account&quot;).</footnote>
        <footnote id="F3">Christopher Shackelton (&quot;Shackelton&quot;) and Adam Gray (&quot;Gray&quot;) are managers of and have an ownership interest in each of CCM and CC and may be deemed to have an indirect pecuniary interest in the shares held by the Funds and the Separate Account due to CCM's right to receive performance-related fees from the Separate Account and CC's right to receive performance-related fees from the Funds. Each of Shackelton, Gray, CCP, CCP2, the Separate Account, CC and CCM disclaims beneficial ownership of these securities except to the extent of that person's pecuniary interest therein.</footnote>
        <footnote id="F4">Following the transactions reported herein, CCP, CCP2 and the Separate Account directly owned  380,186, 98,739 and  153,982 shares of common stock, respectively.</footnote>
        <footnote id="F5">The transaction is not new, but is being reported again to gain access to the system.  The amount of shares of common stock directly owned by CCP, CCP2 and the Separate Account following the transactions reported on August 24, 2015 was originally reported as 380,186, 119,364 and 133,357 shares, respectively.  This amendment to Form 4 reflects the correct amount of shares of common stock directly owned by CCP, CCP2 and the Separate Account following the transactions reported on August 24, 2015 as 380,186, 98,739 and  153,982 shares, respectively.</footnote>
    </footnotes>

    <remarks>Shackelton is a director of the Issuer. As a result, the following persons may be deemed directors by deputization of the Issuer solely for purposes of Section 16 of the Securities Exchange Act of 1934, as amended: CCM, CC, CCP, CCP2, and Gray.</remarks>

    <ownerSignature>
        <signatureName>Coliseum Capital Management, LLC, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Christopher Shackelton</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital, LLC, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital Partners, L.P., By: Coliseum Capital, LLC, its General Partner, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Coliseum Capital Partners II, L.P., By: Coliseum Capital, LLC, its General Partner, By: /s/ Christopher Shackelton, Manager</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Adam Gray, By: /s/ Christopher Shackelton, Attorney-in-fact</signatureName>
        <signatureDate>2015-08-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
