Note 14 - Common Stock Reserved for Issuance - Common Stock Reserved for Issuance (Details) - $ / shares	Mar. 31, 2024	Dec. 31, 2023
Outstanding stock options and RSUs (in dollars per share)	$ 1,048,074	$ 981,834
Shares reserved for future option grants and RSUs (in shares)	254,241	99,580
Total common stock reserved for issuance (in shares)	21,975,516	18,887,958
Lincoln Park [Member]
Total common stock reserved for issuance (in shares)	702,847	711,180
Madryn Noteholders [Member]
Total common stock reserved for issuance (in shares)	1,300,000	1,300,000
EW Investors [Member]
Total common stock reserved for issuance (in shares)	2,000,000	0
Non-Voting Preferred Stock [Member]
Shares reserved for conversion of future preferred share issuance (in shares)	5,764,093	5,844,213
Common Stock [Member]
Outstanding common stock warrants (in shares)	1,936,920	1,061,930
Preferred Stock [Member]
Preferred shares (in shares)	8,969,341	8,889,221