Note 13 - Common Stock Reserved for Issuance - Common Stock Reserved for Issuance (Details) - $ / shares	Dec. 31, 2023	Dec. 31, 2022
Outstanding stock options and RSUs (in dollars per share)	$ 981,834	$ 875,524
Shares reserved for future option grants and RSUs (in shares)	99,580	24,999
Total common stock reserved for issuance (in shares)	18,887,958	6,378,417
Lincoln Park [Member]
Total common stock reserved for issuance (in shares)	711,180	1,054,299
Madryn Noteholders [Member]
Total common stock reserved for issuance (in shares)	1,300,000	547,714
Non-Voting Preferred Stock [Member]
Shares reserved for conversion of future preferred share issuance (in shares)	0	80,617
Voting Preferred Stock [Member]
Shares reserved for conversion of future preferred share issuance (in shares)	5,844,213	609,891
Common Stock [Member]
Outstanding common stock warrants (in shares)	1,061,930	1,061,930
Preferred Stock [Member]
Preferred shares (in shares)	8,889,221	2,123,443