Note 15 - Stockholders Equity - Stock Options Outstanding and Exercisable (Details)	3 Months Ended
	Mar. 31, 2023 $ / shares shares
Options outstanding, number (in shares) | shares	1,009,790
Options outstanding, weighted average remaining contractual term (Year)	8 years 21 days
Options outstanding, weighted average exercise price (in dollars per share)	$ 20.85
Options exercisable (in shares) | shares	249,397
Options exercisable, weighted average remaining contractual term (Year)	5 years 7 days
Options exercisable, weighted average exercise price (in dollars per share)	$ 52.80
Range One [Member]
Exercise price range, lower limit (in dollars per share)	2.82
Exercise price range, upper limit (in dollars per share)	$ 54.60
Options outstanding, number (in shares) | shares	957,723
Options outstanding, weighted average remaining contractual term (Year)	8 years 3 months 10 days
Options outstanding, weighted average exercise price (in dollars per share)	$ 15.75
Options exercisable (in shares) | shares	198,904
Options exercisable, weighted average remaining contractual term (Year)	5 years 3 months 14 days
Options exercisable, weighted average exercise price (in dollars per share)	$ 36.75
Range Two [Member]
Exercise price range, lower limit (in dollars per share)	63.90
Exercise price range, upper limit (in dollars per share)	$ 119.25
Options outstanding, number (in shares) | shares	49,270
Options outstanding, weighted average remaining contractual term (Year)	4 years 3 days
Options outstanding, weighted average exercise price (in dollars per share)	$ 100.35
Options exercisable (in shares) | shares	47,696
Options exercisable, weighted average remaining contractual term (Year)	3 years 11 months 4 days
Options exercisable, weighted average exercise price (in dollars per share)	$ 100.80
Range Three [Member]
Exercise price range, lower limit (in dollars per share)	186.75
Exercise price range, upper limit (in dollars per share)	$ 382.50
Options outstanding, number (in shares) | shares	1,618
Options outstanding, weighted average remaining contractual term (Year)	5 years 6 months
Options outstanding, weighted average exercise price (in dollars per share)	$ 270.90
Options exercisable (in shares) | shares	1,618
Options exercisable, weighted average remaining contractual term (Year)	5 years 6 months
Options exercisable, weighted average exercise price (in dollars per share)	$ 270.90
Range Four [Member]
Exercise price range, lower limit (in dollars per share)	405.00
Exercise price range, upper limit (in dollars per share)	$ 438.75
Options outstanding, number (in shares) | shares	650
Options outstanding, weighted average remaining contractual term (Year)	2 years 3 days
Options outstanding, weighted average exercise price (in dollars per share)	$ 405.15
Options exercisable (in shares) | shares	650
Options exercisable, weighted average remaining contractual term (Year)	2 years 3 days
Options exercisable, weighted average exercise price (in dollars per share)	$ 405.15
Range Five [Member]
Exercise price range, lower limit (in dollars per share)	540.00
Exercise price range, upper limit (in dollars per share)	$ 958.50
Options outstanding, number (in shares) | shares	529
Options outstanding, weighted average remaining contractual term (Year)	4 years 7 months 24 days
Options outstanding, weighted average exercise price (in dollars per share)	$ 684.75
Options exercisable (in shares) | shares	529
Options exercisable, weighted average remaining contractual term (Year)	4 years 7 months 24 days
Options exercisable, weighted average exercise price (in dollars per share)	$ 684.75