Note 15 - Stockholders Equity - Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Outstanding, number of shares (in shares)	849,426
Outstanding, weighted average exercise price (in dollars per share)	$ 25.05
Outstanding, weighted average remaining contractual term (Year)	8 years 21 days		8 years 2 months 23 days
Outstanding, aggregate intrinsic value	$ 96		$ 209
Options granted, number of shares (in shares)	184,333
Options granted, weighted average exercise price (in dollars per share)	$ 2.85
Options granted, aggregate intrinsic value	$ 86
Options exercised, number of shares (in shares)	0
Options exercised, weighted average exercise price (in dollars per share)	$ 0
Options exercised, aggregate intrinsic value	$ 0	$ 1
Options forfeited/cancelled, number of shares (in shares)	(23,969)
Options forfeited/cancelled, weighted average exercise price (in dollars per share)	$ 29.70
Options forfeited/cancelled, aggregate intrinsic value (in dollars per share)	$ 0
Outstanding, number of shares (in shares)	1,009,790		849,426
Outstanding, weighted average exercise price (in dollars per share)	$ 20.85		$ 25.05
Exercisable, number of shares (in shares)	249,397
Exercisable, weighted average exercise price (in dollars per share)	$ 52.80
Exercisable, weighted average remaining contractual term (Year)	5 years 7 days
Exercisable, aggregate intrinsic value	$ 1
Expected to vest, number of shares (in shares)	760,393
Expected to vest, weighted average exercise price (in dollars per share)	$ 10.35
Expected to vest, weighted average remaining contractual term (Year)	9 years 21 days
Expected to vest, aggregate intrinsic value	$ 95