Note 14 - Common Stock Reserved for Issuance - Common Stock Reserved for Issuance (Details) - $ / shares	Mar. 31, 2023	Dec. 31, 2022
Outstanding stock options and RSUs (in dollars per share)	$ 1,012,456	$ 875,343
Shares reserved for future option grants and RSUs (in shares)	71,633	25,080
Total common stock reserved for issuance (in shares)	6,337,465	6,378,307
Lincoln Park [Member]
Total common stock reserved for issuance (in shares)	829,911	1,054,298
Madryn Noteholders [Member]
Total common stock reserved for issuance (in shares)	547,592	547,713
Non-Voting Preferred Stock [Member]
Shares reserved for conversion of future preferred share issuance (in shares)	80,616	80,616
Voting Preferred Stock [Member]
Shares reserved for conversion of future preferred share issuance (in shares)	610,000	610,000
Common Stock [Member]
Outstanding common stock warrants (in shares)	1,061,924	1,061,924
Preferred Stock [Member]
Preferred shares (in shares)	2,123,333	2,123,333