Note 16 - Stockholders Equity (Details Textual) $ / shares in Units, $ in Thousands					1 Months Ended			12 Months Ended		24 Months Ended
	Nov. 18, 2022 USD ($) shares	Jul. 12, 2022 USD ($) $ / shares shares	Dec. 15, 2021 USD ($) $ / shares shares	Jun. 17, 2020 shares	Nov. 30, 2022 USD ($) $ / shares shares	Nov. 30, 2017	Nov. 30, 2010	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) $ / shares shares	Dec. 09, 2020 $ / shares	Jun. 16, 2020 USD ($) $ / shares shares	Oct. 04, 2019 shares
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares								$ 0.0001	$ 0.0001		$ 0.0001
Proceeds from Issuance of Common Stock								$ 2,135	$ 0
Stock Issued During Period, Value, New Issues								2,204
Proceeds from Issuance of Private Placement			$ 16,740
Payments of Stock Issuance Costs								$ 202
Adjustments to Additional Paid in Capital, Convertible Preferred Stock with Beneficial Conversion Feature			152						$ 152
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares								95,674,634	40,931,857
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments								$ 0
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value								$ 0	$ 92
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) | $ / shares								$ 0.62	$ 2.20
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value								$ 1,645	$ 1,545
The 2010 Share Option Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)						10 years	7 years
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares								94,254	212,650
The 2019 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares) | shares													450,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares) | shares								281,947	376,414
Share-based Compensation Arrangement by Share-based Payment Award, Increase in Authorized Shares, Percentage of Outstanding Stock Maximum								4.00%
Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares								7,585,529
Stock Issued During Period, Value, New Issues								$ 1
Proceeds from Issuance of Private Placement			$ 12,074
Adjustments to Additional Paid in Capital, Convertible Preferred Stock with Beneficial Conversion Feature									$ 0
Preferred Stock [Member]
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares								31,850,000	3,790,755
Series A Preferred Stock [Member]
Shares Issued, Price Per Share (in dollars per share) | $ / shares									$ 1.29
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares			$ 0.0001
Proceeds from Issuance of Private Placement			$ 4,514
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares									3,790,755
Preferred Stock, Convertible, Conversion Ratio									1
Preferred Stock, Maximum Conversion Cap Percentage									9.99%
Dividends Payable									$ 0
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares									$ 1.25
Adjustments to Additional Paid in Capital, Convertible Preferred Stock with Beneficial Conversion Feature									$ 152
Series A Preferred Stock [Member] | Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares								0
Stock Issued During Period, Value, New Issues								$ 0
Adjustments to Additional Paid in Capital, Convertible Preferred Stock with Beneficial Conversion Feature									0
Voting Preferred Stock [Member]
Preferred Stock, Convertible, Conversion Ratio					10
Preferred Stock, Liquidation Preference Per Share (in dollars per share) | $ / shares					$ 2.00
Preferred Stock, Convertible, Volume Weighted Average Price Per Common Share (in dollars per share) | $ / shares					$ 1.25
Voting Preferred Stock [Member] | Preferred Stock [Member] | Chief Executive Officer, President, Chief Innovation and Business Officer, and Certain Members of the Board [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares	3,185,000
Equity Purchase Agreement [Member] | Lincoln Park [Member]
Equity Purchase Agreement, Maximum Offering Amount												$ 31,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares												$ 0.0001
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares												7,763,411
Equity Agreement, Maximum Percentage of Stock Outstanding												19.99%
Equity Agreement, Minimum Average Purchase Price (in dollars per share) | $ / shares												$ 3.9755
Maximum Percentage of Outstanding Stock, Beneficial Ownership												9.99%
Stock Issued During Period, Shares, New Issues (in shares) | shares				3,437,087				400,000
Shares Issued, Price Per Share (in dollars per share) | $ / shares										$ 2.70
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares										209,566,000
Stock Issued During Period, Value, Commitment Fee										$ 620
Deferred Offering Costs								$ 0		$ 123
Proceeds from Issuance of Common Stock								$ 272
LPC Purchase Agreement 2022 [Member] | Lincoln Park [Member]
Equity Purchase Agreement, Maximum Offering Amount		$ 11,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares		$ 0.0001
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares		12,873,368
Equity Agreement, Maximum Percentage of Stock Outstanding		19.99%
Maximum Percentage of Outstanding Stock, Beneficial Ownership		9.99%
Stock Issued During Period, Shares, New Issues (in shares) | shares								6,500,000
Shares Issued, Price Per Share (in dollars per share) | $ / shares								$ 0.30
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares		685,529
Stock Issued During Period, Value, Commitment Fee		$ 330
Stock Issued During Period, Value, New Issues								$ 1,970
The 2021 Private Placement [Member]
Proceeds from Issuance of Private Placement			16,999					0	$ 16,740
Payments of Stock Issuance Costs			$ 259
The 2021 Private Placement [Member] | Common Stock [Member]
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares			$ 0.0001						$ 0.0001
Stock Issued During Period, Shares, New Issues (in shares) | shares			9,808,418
The 2021 Private Placement [Member] | Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares									9,808,418
The 2021 Private Placement [Member] | Convertible Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares									3,790,755
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares									$ 0.0001
Preferred Stock, Convertible, Shares Issuable (in shares) | shares									3,790,755
The 2021 Private Placement [Member] | Series A Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares			3,790,755
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares			$ 0.0001
The 2022 Private Placement [Member]
Proceeds from Issuance of Private Placement					$ 6,720			$ 6,518	$ 0
Payments of Stock Issuance Costs					$ 202				$ 259
The 2022 Private Placement [Member] | Chief Executive Officer, President, Chief Innovation and Business Officer, and Certain Members of the Board [Member]
Proceeds from Issuance of Private Placement	$ 6,720
The 2022 Private Placement [Member] | Common Stock [Member]
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares					$ 0.0001
Stock Issued During Period, Shares, New Issues (in shares) | shares					1,750,000
The 2022 Private Placement [Member] | Common Stock [Member] | Chief Executive Officer, President, Chief Innovation and Business Officer, and Certain Members of the Board [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares	1,750,000
The 2022 Private Placement [Member] | Convertible Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares					3,185,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares					$ 0.0001
Preferred Stock, Convertible, Shares Issuable (in shares) | shares					31,850,000
The 2022 Private Placement [Member] | Series A Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares					3,185,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares					$ 0.0001
The 2022 Private Placement [Member] | Voting Preferred Stock [Member] | Chief Executive Officer, President, Chief Innovation and Business Officer, and Certain Members of the Board [Member]
Preferred Stock, Convertible, Conversion Ratio	10
The 2022 Private Placement [Member] | Voting Preferred Stock [Member] | Preferred Stock [Member] | Chief Executive Officer, President, Chief Innovation and Business Officer, and Certain Members of the Board [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares	3,185,000