Note 14 - Stockholders Equity - Stock Options Outstanding and Exercisable (Details)	3 Months Ended
	Mar. 31, 2022 $ / shares shares
Range One [Member]
Options outstanding, number (in shares) | shares	6,409,764
Options outstanding, weighted average remaining contractual term (Year)	7 years 11 months 8 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 2.26
Options exercisable (in shares) | shares	2,007,671
Options exercisable, weighted average remaining contractual term (Year)	4 years 8 months 1 day
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 2.92
Range Two [Member]
Options outstanding, number (in shares) | shares	1,062,568
Options outstanding, weighted average remaining contractual term (Year)	4 years 9 months 18 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 6.76
Options exercisable (in shares) | shares	967,064
Options exercisable, weighted average remaining contractual term (Year)	4 years 6 months 21 days
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 6.76
Range Three [Member]
Options outstanding, number (in shares) | shares	30,119
Options outstanding, weighted average remaining contractual term (Year)	5 years 8 months 26 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 18.02
Options exercisable (in shares) | shares	26,069
Options exercisable, weighted average remaining contractual term (Year)	5 years 7 months 6 days
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 18.11
Range Four [Member]
Options outstanding, number (in shares) | shares	11,634
Options outstanding, weighted average remaining contractual term (Year)	2 years 9 months 3 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 27.64
Options exercisable (in shares) | shares	11,622
Options exercisable, weighted average remaining contractual term (Year)	2 years 9 months
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 27.64
Range Five [Member]
Options outstanding, number (in shares) | shares	8,379
Options outstanding, weighted average remaining contractual term (Year)	5 years 4 months 28 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 45.42
Options exercisable (in shares) | shares	8,379
Options exercisable, weighted average remaining contractual term (Year)	5 years 4 months 28 days
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 45.42
Range Six [Member]
Options outstanding, number (in shares) | shares	7,522,464
Options outstanding, weighted average remaining contractual term (Year)	7 years 5 months 19 days
Options outstanding, weighted average exercise price (in dollars per share) | $ / shares	$ 3.05
Options exercisable (in shares) | shares	3,020,805
Options exercisable, weighted average remaining contractual term (Year)	4 years 7 months 20 days
Options exercisable, weighted average exercise price (in dollars per share) | $ / shares	$ 4.50