X0508 4 2026-02-02 0001408443 Milestone Pharmaceuticals Inc. MIST 0001943112 Nelson Jeffrey Edward C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTREAL A8 H4M 2X6 QUEBEC, CANADA false true false false Chief Operating Officer 0 Employee Stock Option (right to buy) 1.97 2026-02-02 4 A 0 204000 0 A 2036-02-02 Common Shares 204000 204000 D Restricted Stock Unit 2026-02-02 4 A 0 136000 0 A Common Shares 136000 136000 D One-fourth (1/4th) of the shares subject to the option vest on February 2, 2027, and one thirty-sixth (1/36th) of the remaining shares subject to this option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date. Each restricted stock unit represents a contingent right to receive one common share. One-fourth (1/4th) of the shares subject to the restricted stock unit award vest on each of February 2, 2027, February 2, 2028, February 2, 2029 and February 2, 2030, subject to the Reporting Person continuing to provide service through each such date. /s/ Joseph Oliveto, Attorney-in-Fact 2026-02-04