Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Cash flows used in operating activities
Net loss	$ (41,519)	$ (59,685)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation of property and equipment	105	92
Amortization of debt costs	370	244
Accretion of investment discount	(454)	(162)
Non-cash interest expense related to debt	3,210	2,310
Share-based compensation expense	5,776	9,534
Loss on disposals of property and equipment	8
Changes in operating assets and liabilities:
Other receivables	1,718	(2,326)
Research and development tax credits receivable	(258)	(312)
Prepaid expenses	1,338	2,827
Operating lease assets and liabilities	(17)	18
Accounts payable and accrued liabilities	875	1,036
Net cash used in operating activities	(28,848)	(46,424)
Cash provided by (used in) investing activities
Acquisition of property and equipment	(33)	(112)
Acquisition of short-term investments	(113,554)	(137,132)
Redemption of short-term investments	121,870	142,000
Net cash provided by investing activities	8,283	4,756
Cash provided by financing activities
Proceeds from exercise of options	53	189
Proceeds from issuance of senior secured convertible debt		50,000
Pre-funded warrant issuance costs	4,617	(8)
Proceeds from issuance of common shares, net of issuance costs	27,258
Proceeds from employee stock purchase plan	191	393
Payment of debt issuance costs		(2,782)
Cash provided by financing activities	32,119	47,792
Net increase in cash and cash equivalents	11,554	6,124
Cash and cash equivalents - Beginning of year	13,760	7,636
Cash and cash equivalents - End of year	$ 25,314	$ 13,760