Share Based Compensation - Non-vested share options (Details) - $ / shares	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Plans 2011 and 2019 and 2021 Inducement
Number of options
Non-vested at beginning of year	3,581,642
Non-vested share options at end of year	2,930,763	3,581,642
Weighted average fair value
Non-vested at beginning of year	$ 3.69
Non-vested at end of year	$ 2.45	$ 3.69
2011 Plan
Number of options
Non-vested at beginning of year		2,126
Vested, outstanding		(2,126)
Weighted average fair value
Non-vested at beginning of year		$ 6.64
Vested, outstanding		$ 6.64
2019 Plan
Number of options
Non-vested at beginning of year	3,178,475	2,923,763
Granted	1,652,000	1,875,400
Vested, outstanding	(1,690,368)	(1,504,329)
Forfeited	(386,053)	(116,359)
Non-vested share options at end of year	2,754,054	3,178,475
Weighted average fair value
Non-vested at beginning of year	$ 3.64	$ 5.3
Granted	1.26	2.87
Vested, outstanding	3.48	5.88
Forfeited	3.47	3.96
Non-vested at end of year	$ 2.33	$ 3.64
2021 Inducement Plan
Number of options
Non-vested at beginning of year	403,167	503,000
Granted		122,000
Vested, outstanding	(128,208)	(221,833)
Non-vested share options at end of year	176,709	403,167
Weighted average fair value
Non-vested at beginning of year	$ 4.07	$ 4.84
Granted		2.3
Vested, outstanding	4.48	4.85
Forfeited	4.33
Non-vested at end of year	$ 4.19	$ 4.07