Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Common Shares	Pre-funded warrants	Additional paid-in capital	Accumulated deficit	Total
Opening balance at Dec. 31, 2022	$ 273,900	$ 34,352	$ 24,437	$ (266,341)	$ 66,348
Beginning Balance, warrants (in shares) at Dec. 31, 2022		8,518,257
Beginning Balance (in shares) at Dec. 31, 2022	34,286,002
Increase (Decrease) in Stockholders' Equity
Net loss				(59,685)	(59,685)
Exercise of stock options	$ 326		(137)		189
Exercise of stock options (in shares)	114,103
Pre-funded warrants - Private Placement, net of issuance costs		$ 14,107			14,107
Pre-funded warrants - Private Placement, net of issuance costs (in shares)		1,059,000
Share-based compensation			9,534		9,534
Exchange of common shares	$ (14,115)				(14,115)
Exchange of common shares (in shares)	(1,059,000)
Employee stock purchase plan purchases	$ 393				393
Employee stock purchase plan purchases (in shares)	142,006
Closing balance at Dec. 31, 2023	$ 260,504	$ 48,459	33,834	(326,026)	$ 16,771
Ending Balance, warrants (in shares) at Dec. 31, 2023		9,577,257			9,577,257
Ending Balance (in shares) at Dec. 31, 2023	33,483,111				33,483,111
Increase (Decrease) in Stockholders' Equity
Net loss				(41,519)	$ (41,519)
Exercise of stock options	$ 95		(42)		53
Exercise of stock options (in shares)	50,476
Pre-funded warrants - Private Placement, net of issuance costs		$ 4,617			4,617
Pre-funded warrants - Private Placement, net of issuance costs (in shares)		3,333,333
Share-based compensation			5,776		5,776
Issuance of common shares, net of issuance costs	$ 27,258				27,258
Issuance of common shares, net of issuance costs (shares)	19,666,667
Employee stock purchase plan purchases	$ 191				191
Employee stock purchase plan purchases (in shares)	153,730
Closing balance at Dec. 31, 2024	$ 288,048	$ 53,076	$ 39,568	$ (367,545)	$ 13,147
Ending Balance, warrants (in shares) at Dec. 31, 2024		12,910,590			12,910,590
Ending Balance (in shares) at Dec. 31, 2024	53,353,984				53,353,984