Share Based Compensation (Tables)

12 Months Ended

Dec. 31, 2024

Share Based Compensation

Schedule of outstanding and exercisable options

	2024
								Weighted
	Number							average
	of shares							exercise
	2019 Plan			Inducement Plan	2011 Plan		Total	price
Outstanding at beginning of year - 2011 Plan		—		—		1,694,233	1,694,233	$	2.09
Outstanding at beginning of year - 2019 Plan		6,406,897		—		—	6,406,897		5.82
Outstanding at beginning of year - Inducement Plan		—		625,000		—	625,000		5.74
Granted - 2019 Plan		1,652,000		—		—	1,652,000		1.62
Exercised - 2011 Plan		—		—		(50,476)	(50,476)		1.04
Forfeited - Inducement Plan		—		(98,250)		—	(98,250)		4.33
Forfeited - 2019 Plan		(386,053)		—		—	(386,053)		4.42
Expired - 2019 Plan		(68,238)		—		—	(68,238)		7.42
Expired - 2011 Plan		—		—		(11,272)	(11,272)		4.01
Expired - Inducement Plan		—		(30,750)		—	(30,750)		6.22
Outstanding at end of year		7,604,606		496,000		1,632,485	9,733,091	$	4.54
Outstanding at end of year - Weighted average exercise price	$	4.97	$	5.99	$	2.11
Exercisable at end of year		4,850,552		319,291		1,632,485	6,802,328	$	5.14
Exercisable at end of year - Weighted average exercise price	$	6.09	$	6.24	$	2.11

	2023
								Weighted
	Number							average
	of shares							exercise
	2019 Plan			Inducement Plan	2011 Plan		Total	price
Outstanding at beginning of year - 2011 Plan		—		—		1,802,672	1,802,672	$	2.05
Outstanding at beginning of year - 2019 Plan		5,314,312		—		—	5,314,312		8.35
Outstanding at beginning of year - Inducement Plan		—		503,000		—	503,000		6.41
Granted - 2019 Plan		1,875,400		—		—	1,875,400		3.61
Granted - Inducement Plan		—		122,000		—	122,000		2.98
Exercised - 2019 Plan		(7,000)		—		—	(7,000)		3.74
Exercised - 2011 Plan		—		—		(107,103)	(107,103)		1.52
Forfeited - 2019 Plan		(156,198)		—		—	(156,198)		6.13
Expired - 2019 Plan		(58,617)		—		—	(58,617)		11.52
Expired - 2011 Plan		—		—		(1,336)	(1,336)		0.91
Cancelled - 2019 Plan		(561,000)		—		—	(561,000)		21.73
Outstanding at end of year		6,406,897		625,000		1,694,233	8,726,130	$	5.09
Outstanding at end of year - Weighted average exercise price	$	5.82	$	5.74	$	2.09
Exercisable at end of year		3,228,422		221,833		1,694,233	5,144,488	$	5.32
Exercisable at end of year - Weighted average exercise price	$	6.93		6.42	$	2.09

Schedule of non-vested share options activity

	2024
	Number							Weighted
	of options							average
	2019 Plan		Inducement Plan		2011 Plan		Total	fair value
Non-vested share options at beginning of year - 2019 Plan		3,178,475		—		—	3,178,475		3.64
Non-vested share options at beginning of year - Inducement Plan		—		403,167		—	403,167		4.07
Granted - 2019 Plan		1,652,000		—		—	1,652,000		1.26
Vested, outstanding - 2019 Plan		(1,690,368)		—		—	(1,690,368)		3.48
Vested, outstanding - Inducement Plan		—		(128,208)		—	(128,208)		4.48
Forfeited - Inducement Plan		—		(98,250)		—	(98,250)		3.31
Forfeited - 2019 Plan		(386,053)		—		—	(386,053)		3.47
Non-vested share options at end of year		2,754,054		176,709		—	2,930,763	$	2.45
Non-vested share options at end of year - Weighted average fair value	$	2.33	$	4.19	$	—

	2023
	Number							Weighted
	of options							average
	2019 Plan		Inducement Plan		2011 Plan		Total	fair value
Non-vested share options at beginning of year - 2011 Plan		—		—		2,126	2,126	$	6.64
Non-vested share options at beginning of year - 2019 Plan		2,923,763		—		—	2,923,763		5.30
Non-vested share options at beginning of year - Inducement Plan		—		503,000		—	503,000		4.84
Granted - 2019 Plan		1,875,400		—		—	1,875,400		2.87
Granted - Inducement Plan		—		122,000		—	122,000		2.30
Vested, outstanding - 2011 Plan		—		—		(2,126)	(2,126)		6.64
Vested, outstanding - 2019 Plan		(1,504,329)		—		—	(1,504,329)		5.88
Vested, outstanding - Inducement Plan		—		(221,833)		—	(221,833)		4.85
Forfeited - 2019 Plan		(116,359)		—		—	(116,359)		3.96
Non-vested share options at end of year		3,178,475		403,167		—	3,581,642.00	$	3.69
Non-vested share options at end of year - Weighted average fair value	$	3.64	$	4.07	$	—

Schedule of information of options outstanding and exercisable

	Options outstanding				Options exercisable
		Weighted				Weighted
		average	Weighted			average	Weighted
		remaining	average			remaining	average
	Number	contractual	exercise		Number	contractual	exercise
Exercise price	of options	life (years)	price		of options	life (years)	price
$0.84-$1.73	1,623,845	5.74		1.46	1,089,175	3.83		1.46
$1.74-$3.2	1,725,554	7.06		2.16	733,262	4.04		2.61
$3.21-$5.25	2,128,500	7.40		3.67	1,393,090	7.02		3.70
$5.26-$6.36	3,368,756	6.68		5.90	2,857,032	6.63		5.95
$6.37-$8.5	527,000	7.06		6.82	379,083	6.98		6.80
$8.51-$15.5	53,086	5.49		9.08	44,336	5.06		9.19
$15.51-$20.5	65,100	4.84		17.21	65,100	4.84		17.21
$20.51-$22.45	241,250	5.06		21.48	241,250	5.06		21.48
Total	9,733,091	6.71	$	4.54	6,802,328	5.92	$	5.14

Schedule of weighted average assumptions for the options granted

	Year ended December 31,
	2024			2023
Exercise price	$	1.62		$	3.58
Share price	$	1.62		$	3.58
Volatility		96	%		97	%
Risk-free interest rate		4.17	%		3.97	%
Expected life		5.66 years			6.01 years
Dividend		0	%		0	%

Schedule of PSU activity

	2024		2023
Beginning balance	$	—	$	—
Granted		924,000		—
Vested		—		—
Forfeited		—		—
Ending balance	$	924,000	$	—

Schedule of share-based compensation expense

	2024		2023
Administration	$	3,171	$	4,849
Research and development		1,874		3,281
Commercial activities		731		1,404
Total	$	5,776	$	9,534