Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows used in operating activities
Net loss	$ (45,211)	$ (25,969)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation of property and equipment	74	70
Share-based compensation expense	6,905	5,304
Changes in operating assets and liabilities:
Other receivables	(308)	134
Research and development tax credits receivable	161	450
Prepaid expenses	(759)	(540)
Operating lease assets and liabilities	47	25
Accounts payable and accrued liabilities	(516)	(321)
Net cash used in operating activities	(39,607)	(20,847)
Cash provided by (used in) investing activities
Acquisition of property and equipment	(162)
Acquisition of short-term investments	(62,947)	(15,000)
Redemption of short-term investments	23,000	70,000
Net cash provided by (used in) investing activities	(40,109)	55,000
Cash provided by financing activities
Proceeds from exercise of options	217	43
Issuance of common shares, net of issuance costs	2,644
Net Proceeds from issuance of pre-funded warrants in a private placement		4,920
Cash provided by financing activities	2,861	4,963
Net decrease in cash and cash equivalents	(76,855)	39,116
Cash and cash equivalents - Beginning of period	114,141	72,310
Cash and cash equivalents - End of period	$ 37,286	$ 111,426