Share Based Compensation - Recognized share-based compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-based compensation
Share-based compensation expense	$ 2,380	$ 2,024	$ 6,905	$ 5,304
Administration
Share-based compensation
Share-based compensation expense	1,891	863	3,683	2,186
Research and development
Share-based compensation
Share-based compensation expense	349	821	2,302	2,226
Commercial activities
Share-based compensation
Share-based compensation expense	$ 140	$ 340	$ 920	$ 892