X0306 4 2022-12-01 0 0001408443 Milestone Pharmaceuticals Inc. MIST 0001910985 Bharucha David C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTREAL A8 H4M 2X6 QUEBEC, CANADA 0 1 0 0 Chief Medical Officer Common Shares 2022-12-01 4 P 0 3000 4.86 A 3000 D Common Shares 2022-12-05 4 P 0 7000 4.69 A 10000 D /s/ Jason Minio, Attorney-in-Fact 2022-12-05