X0306 4 2022-10-19 0 0001408443 Milestone Pharmaceuticals Inc. MIST 0001570392 TOMSICEK MICHAEL JOHN C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTR?AL A8 H4M 2X6 QUEBEC, CANADA 1 0 0 0 Common Shares 2022-10-19 4 P 0 15000 5.32 A 15000 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions within a one dollar range. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Jason Minio, Attorney-in-Fact 2022-10-21