X0306 4 2022-09-14 0 0001408443 Milestone Pharmaceuticals Inc. MIST 0001772891 Liebert Debra K. C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTR?AL A8 H4M 2X6 QUEBEC, CANADA 1 0 0 0 Common Shares 2022-09-14 4 J 0 127 0.00 A 127 D Represents a pro rata distribution without additional consideration to the Reporting Person from a limited liability company in which the Reporting Person is a member. /s/ Jason Minio, Attorney-in-Fact 2022-09-15