X0306 4 2022-05-31 0 0001408443 Milestone Pharmaceuticals Inc. MIST 0001120362 TRUEX PAUL F C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTR?AL A8 H4M 2X6 QUEBEC, CANADA 1 0 0 0 Common Shares 2022-05-31 4 M 0 8016 1.12 A 8016 D Common Shares 2022-05-31 4 M 0 45072 1.54 A 53088 D Common Shares 2022-05-31 4 M 0 22870 1.54 A 75958 D Common Shares 2022-05-31 4 M 0 822 2.66 A 76780 D Common Shares 2022-05-31 4 P 0 5000 5.60 A 81780 D Stock Option (right to buy) 1.12 2022-05-31 4 M 0 8016 0.00 D 2025-08-26 Common Shares 8016 0 D Stock Option (right to buy) 1.54 2022-05-31 4 M 0 45072 0.00 D 2027-07-21 Common Shares 45072 0 D Stock Option (right to buy) 1.54 2022-05-31 4 M 0 22870 0.00 D 2028-10-15 Common Shares 22870 2659 D Stock Option (right to buy) 2.66 2022-05-31 4 M 0 822 0.00 D 2028-11-20 Common Shares 822 117 D Fully vested and exercisable. Twenty-five percent (25%) of the shares subject to the option shall vest on October 15, 2019, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date. Twenty-five percent (25%) of the shares subject to the option shall vest on November 21, 2019, and one thirty-sixth (1/36th) of the remaining shares subject to the option shall vest each month thereafter, subject to the Reporting Person continuing to provide service through each such date. /s/ Jason Minio, Attorney-in-Fact 2022-06-01