X0306 4 2021-06-14 0 0001408443 Milestone Pharmaceuticals Inc. MIST 0001120362 TRUEX PAUL F C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTR?AL A8 H4M 2X6 QUEBEC, CANADA 1 0 0 0 Stock Option (right to buy) 5.54 2021-06-14 4 A 0 30000 0.00 A 2031-06-14 Common Shares 30000 30000 D This option will vest in twelve (12) equal monthly installments, beginning on July 14, 2021, provided that the option will in any case be fully vested on the date of next annual meeting of the stockholders of the Issuer, subject to the Reporting Person continuing to provide service through each such vesting date. /s/ Jason Minio, Attorney-in-Fact 2021-07-29