X0303 4 2010-03-15 0 0000319240 IRIS INTERNATIONAL INC IRIS 0001408320 Donato Peter C/O IRIS INTERNATIONAL, INC. 9172 ETON AVENUE CHATSWORTH CA 91311 0 1 0 0 Corporate V.P. & C.F.O. Common Stock 2010-03-15 4 S 0 146 10.3855 D 10885 D Common Stock 2010-03-15 4 S 0 146 10.3955 D 10739 D Common Stock 2010-03-15 4 S 0 146 10.4 D 10593 D Common Stock 2010-03-15 4 S 0 146 10.4062 D 10447 D Common Stock 2010-03-15 4 S 0 146 10.4155 D 10301 D Common Stock 2010-03-15 4 S 0 146 10.42 D 10155 D Common Stock 2010-03-15 4 S 0 146 10.4365 D 10009 D Common Stock 2010-03-15 4 S 0 146 10.5185 D 9863 D Common Stock 2010-03-15 4 S 0 145 10.5262 D 9718 D Common Stock 2010-03-15 4 S 0 292 10.53 D 9426 D Common Stock 2010-03-15 4 S 0 146 10.55 D 9280 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan previously adopted by the reporting person. /s/ Peter Donato 2010-03-16