<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-05-27</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0000353569</issuerCik>
        <issuerName>QUIDEL CORP /DE/</issuerName>
        <issuerTradingSymbol>QDEL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001406652</rptOwnerCik>
            <rptOwnerName>BRYANT DOUGLAS C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>9975 SUMMERS RIDGE ROAD</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President &amp; CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

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                <value>Common Stock</value>
            </securityTitle>
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            </transactionDate>
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            <transactionTimeliness>
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            </transactionTimeliness>
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                </transactionShares>
                <transactionPricePerShare>
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                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
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                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

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            <expirationDate>
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                    <value>0.00</value>
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                    <value>D</value>
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    </derivativeTable>

    <footnotes>
        <footnote id="F1">Pursuant to the Business Combination Agreement, dated as of December 22, 2021 (the &quot;Business Combination Agreement&quot;) by and among Quidel Corporation (&quot;Quidel&quot;), Ortho Clinical Diagnostics Holdings plc, QuidelOrtho Corporation (&quot;QuidelOrtho&quot;), Orca Holdco, Inc., Laguna Merger Sub, Inc. and Orca Holdco 2, Inc., each share of common stock of Quidel beneficially owned by the Reporting Person at the effective time of the transaction contemplated by the Business Combination Agreement will be exchanged for one share of common stock of QuidelOrtho.</footnote>
        <footnote id="F2">Pursuant to the Business Combination Agreement, the Quidel Non-Qualified Stock Options will be converted into an equal number of Non-Qualified Stock Options to purchase shares of common stock of QuidelOrtho on the same terms and conditions (including applicable vesting conditions).</footnote>
        <footnote id="F3">Vested in full.</footnote>
        <footnote id="F4">28,080 shares are vested in full; 9,360 shares will vest on February 4, 2023.</footnote>
        <footnote id="F5">15,180 shares are vested in full; the remaining 15,178 shares will vest in equal installments on February 3, 2023 and February 3, 2024.</footnote>
        <footnote id="F6">3,531 shares are vested in full; the remaining 7,062 shares will vest in equal installments on August 24, 2022 and August 24, 2023.</footnote>
        <footnote id="F7">2,231 shares are vested in full; the remaining 6,693 shares will vest in equal installments on February 1, 2023, February 1, 2024 and February 1, 2025.</footnote>
        <footnote id="F8">3,713 shares will vest on July 28, 2022; 3,713 shares will vest on July 28, 2023; and 3,714 shares will vest on July 28, 2024.</footnote>
        <footnote id="F9">6,760 shares will vest on January 31, 2023; the remaining 20,283 shares will vest in equal installments on January 31, 2024, January 31, 2025 and January 31, 2026.</footnote>
        <footnote id="F10">Each restricted stock unit represents the right to receive one share of Quidel common stock.</footnote>
        <footnote id="F11">Pursuant to the Business Combination Agreement, the Quidel restricted stock units will be converted into an equal number of restricted stock units representing the right to receive shares of common stock of QuidelOrtho on the same terms and conditions (including applicable vesting conditions).</footnote>
        <footnote id="F12">18,720 shares will vest on February 4, 2023.</footnote>
        <footnote id="F13">Release of restricted stock units was deferred pursuant to Quidel's deferred compensation program applicable to participating employees and will occur according to the elected deferral schedule.</footnote>
        <footnote id="F14">7,590 shares will vest in equal installments on February 3, 2023 and February 3, 2024.</footnote>
        <footnote id="F15">1,460 shares will vest on August 24, 2022 and 1,461 shares will vest on August 24, 2023.</footnote>
        <footnote id="F16">1,115 shares will vest on February 1, 2023; the remaining 2,232 shares will vest in equal installments on February 1, 2024 and February 1, 2025.</footnote>
        <footnote id="F17">6,760 shares will vest on January 31, 2023; the remaining 20,283 shares will vest in equal installments on January 31, 2024, January 31, 2025 and January 31, 2026.</footnote>
        <footnote id="F18">12,093 shares will vest on January 31, 2024; the remaining 12,094 shares will vest in equal installments on January 31, 2025 and January 31, 2026.</footnote>
        <footnote id="F19">794 shares will vest on January 31, 2023.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Phillip S. Askim, attorney-in-fact for Douglas C. Bryant</signatureName>
        <signatureDate>2022-06-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
