X0306 4 2018-12-14 0 0001598646 Minerva Neurosciences, Inc. NERV 0001405279 Ahlholm Frederick W C/O MINERVA NEUROSCIENCES, INC. 1601 TRAPELO ROAD, SUITE 286 WALTHAM MA 02451 0 1 0 0 SVP, Chief Accounting Officer Common Stock 2018-12-14 4 M 0 5000 A 13339 D Common Stock 2018-12-17 4 S 0 1559 7.46 D 11780 D Restricted Stock Unit 2018-12-14 4 M 0 5000 0.00 D Common Stock 5000 10000 D Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Shares sold to satisfy withholding tax obligations upon the vesting of restricted stock grants. Represents shares issuable upon the vesting of RSUs awarded to the Reporting Person on December 14, 2016. The RSUs vest in 4 equal annual installments beginning on December 14, 2017 and will be fully vested on December 14, 2020, in all cases so long as there has been no break in the Reporting Person's continuous service through such date. /s/ Ryan Sansom, Attorney-in-Fact 2018-12-18