<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><Version>2.4.0.8</Version><ReportLongName>0006 - Disclosure - DESCRIPTION OF BUSINESS AND GOING CONCERN</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column FlagID="0"><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelSeparator>

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</LabelSeparator><Level>1</Level><ElementName>us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</ElementName><ElementPrefix>us-gaap_</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsCalendarTitle>false</IsCalendarTitle><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><FootnoteIndexer /><Cells><Cell FlagID="0" ContextID="" UnitID=""><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText /><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat></Cell></Cells><ElementDataType>xbrli:stringItemType</ElementDataType><SimpleDataType>string</SimpleDataType><IsTotalLabel>false</IsTotalLabel><UnitID>0</UnitID><Label>Organization, Consolidation and Presentation of Financial Statements [Abstract]</Label></Row><Row FlagID="0"><Id>2</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelSeparator>

</LabelSeparator><Level>2</Level><ElementName>us-gaap_BusinessDescriptionAndBasisOfPresentationTextBlock</ElementName><ElementPrefix>us-gaap_</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsCalendarTitle>false</IsCalendarTitle><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><FootnoteIndexer /><Cells><Cell FlagID="0" ContextID="From2013-03-01to2013-05-31" UnitID=""><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;MetaStat, Inc. (&amp;#147;we,&amp;#148; &amp;#147;us,&amp;#148;
&amp;#147;our,&amp;#148; the &amp;#147;Company,&amp;#148; or &amp;#147;MetaStat&amp;#148;) is a development stage life sciences company focused on
developing and commercializing novel diagnostic technologies and therapeutics for the early and reliable prediction and treatment
of systemic metastasis - cancer that spreads from a primary tumor through the bloodstream to other areas of the body. Systemic
metastasis is responsible for ~90% of all solid tumor cancer related deaths and as such, we believe the more effective treatment
of metastatic disease and/or the prevention of systemic metastasis is needed to improve patient outcomes.&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"&gt;&amp;#160;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;&lt;i&gt;Basis of Presentation&lt;/i&gt;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"&gt;&amp;#160;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;The accompanying unaudited consolidated
financial statements include the accounts of the Company and its wholly-owned subsidiary, MetasStat BioMedical, Inc., a Delaware
corporation. All significant intercompany balances and transactions have been eliminated in consolidation.&amp;#160; These&amp;#160;interim
financial statements have been prepared in conformity with generally accepted accounting principles (&amp;#147;GAAP&amp;#148;) in the
United States consistent with those applied in, and should be read in conjunction with, the Company&amp;#146;s audited consolidated
financial statements and related footnotes for the year ended February 28, 2013 included in the Company&amp;#146;s Annual Report on
Form 10-K as filed with the United States Securities and Exchange Commission (&amp;#147;SEC&amp;#148;) on May 28, 2013. These financial
statements reflect all adjustments, consisting only of normal recurring adjustments, which are, in the opinion of management, necessary
for a fair presentation of the Company&amp;#146;s financial position as of May 31, 2013 and its results of operations and cash flows
for the interim periods presented and are not necessarily indicative of results for subsequent interim periods or for the full
year. These interim financial statements do not include all of the information and footnotes required by GAAP for complete financial
statements and allowed by the relevant SEC rules and regulations; however, the Company believes that its disclosures are adequate
to ensure that the information presented is not misleading. Certain amounts in prior periods have been reclassified to conform
to current presentation.&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"&gt;&amp;#160;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;&lt;i&gt;Going Concern&lt;/i&gt;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"&gt;&amp;#160;&lt;/p&gt;

&lt;p style="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;&lt;/p&gt;

&lt;p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"&gt;These financial statements have been prepared
on a going concern basis, which implies the Company will continue to realize its assets and discharge its liabilities in the normal
course of business. As of May 31, 2013, the Company has an accumulated deficit of $8,184,422. The continuation of the Company as
a going concern is dependent upon continued financial support from its shareholders, the ability of the Company to obtain necessary
equity and/or debt financing to continue operations, and the attainment of profitable operations. These factors raise substantial
doubt regarding the Company&amp;#146;s ability to continue as a going concern. The Company cannot make any assurances that additional
financings will be completed on a timely basis, on acceptable terms or at all. If the Company is unable to complete a debt or equity
offering, or otherwise obtain sufficient financing when and if needed, it would negatively impact it&amp;#146;s business and operations,
which could cause the price of its common stock to decline. It could also lead to the reduction or suspension of the Company&amp;#146;s
operations and ultimately force the Company to go out of business. These financial statements do not include any adjustments to
the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should
the Company be unable to continue as a going concern.&lt;/p&gt;



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