Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Reconciliation Of Income Taxes [Line Items]
Federal statutory income tax rate	21.00%	21.00%	21.00%
Increase in valuation allowance	$ 119,300,000	$ 47,000,000.0	$ 47,300,000
Valuation allowance changes, description	The Company does not expect any significant changes in its valuation allowance positions within the next 12 months.
Federal net operating loss carryforwards	$ 1,200,000,000	760,000,000.0
State net operating loss carryforward	737,800,000	507,700,000
International net operating loss carryforwards	8,000,000.0	8,000,000.0
Research and development tax credits, net of UTP	$ 62,710,000	46,729,000
Minimum percentage chances of tax benefit to be realized on examination	50.00%
Unrecognized tax benefits affect the Company's effective tax rate	$ 0
Interest or penalties recorded	$ 0
Expected significant change in unrecognized tax benefits, description	The Company does not expect any significant change in its unrecognized tax benefits within the next 12 months.
Federal [Member]
Reconciliation Of Income Taxes [Line Items]
Net operating loss, carryforwards, period	20 years
Net operating loss carryforwards, begin to expiration year	2027
Interest expense carryforward	$ 39,900,000	$ 35,200,000
Research and development tax credits, net of UTP	$ 44,800,000
Research and development tax credit carryforwards, begin to expiration year	2027
State [Member]
Reconciliation Of Income Taxes [Line Items]
Net operating loss carryforwards, begin to expiration year	2023
Research and development tax credits, net of UTP	$ 17,900,000
Research and development tax credit carryforwards, begin to expiration year	2022