Workforce reduction (Details) - USD ($) $ in Thousands		3 Months Ended	12 Months Ended
	Nov. 14, 2022	Mar. 31, 2023	Dec. 31, 2022
Restructuring Cost and Reserve [Line Items]
Number of positions eliminated, period percent	40.00%
Expected cost	$ 1,800
Charges			$ 1,407
Amounts Paid			366
Accrued at period end			1,041
Forecast
Restructuring Cost and Reserve [Line Items]
Charges		$ 400
General and administrative expenses
Restructuring Cost and Reserve [Line Items]
Charges			200
Research and development expenses
Restructuring Cost and Reserve [Line Items]
Charges			1,200
November 2022 Reductions
Restructuring Cost and Reserve [Line Items]
Charges			1,407
Amounts Paid			366
Accrued at period end			$ 1,041