Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2019		37,996,849
Beginning balance at Dec. 31, 2019	$ 141,687		$ 441,216	$ (299,529)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock and pre funded warrants, net of commissions and offering expenses (in shares)		3,262,471
Issuance of common stock and pre funded warrants, net of commissions and offering expenses	71,320		71,320
Common stock issued upon exercises of stock options (in shares)		882,624
Common stock issued upon exercises of stock options	5,665		5,665
Common stock issued upon vesting of restricted stock units (in shares)		36,000
Issuance of shares under Employee Stock Purchase Plan (in shares)		18,352
Issuance of common stock under Employee Stock Purchase Plan	199		199
Stock-based compensation	5,622		5,622
Net loss	(33,277)			(33,277)
Ending balance (in shares) at Dec. 31, 2020		42,196,296
Ending balance at Dec. 31, 2020	$ 191,216		524,022	(332,806)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Common stock issued upon exercises of stock options (in shares)	124,928	124,928
Common stock issued upon exercises of stock options	$ 411		411
Common stock issued upon vesting of restricted stock units (in shares)		84,500
Issuance of shares under Employee Stock Purchase Plan (in shares)		51,747
Issuance of common stock under Employee Stock Purchase Plan	372		372
Stock-based compensation	11,557		11,557
Net loss	(60,692)			(60,692)
Ending balance (in shares) at Dec. 31, 2021		42,457,471
Ending balance at Dec. 31, 2021	$ 142,864		$ 536,362	$ (393,498)