Income taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Schedule of Income Tax Recovery

Income tax recovery varies from the amounts that would be computed by applying the expected U.S. federal income tax rate (21%) as shown in the following table:

	December 31,
	2021		2020
Statutory federal income tax rate	(21.0)	%	(21.0)	%
Foreign rate differential	—		(0.1)
Stock-based compensation	2.0		1.8
Disposal of Aquinox Canada	—		(5.2)
Change in valuation allowance	21.2		26.5
Expiration of NOLs (section 382)	—		0.5
Tax credits	(2.2)		(2.5)
Income tax recovery	—	%	—	%

Schedule of Net (Loss) Income Before Taxes

Net loss before taxes (in thousands):	Years Ended December 31,
	2021		2020
Canada	$	—	$	(522)
U.S.	(60,692)		(32,755)
Total	$	(60,692)	$	(33,277)

Components of Deferred Income Tax Assets

The significant components of the deferred income tax assets are as follows (in thousands):

	December 31,
	2021		2020
Deferred tax assets:
U.S. net operating losses	$	22,863	$	12,328
Research and development deductions and credits	2,414		1,040
Intangibles	457		422
Lease liability	2,701		2,513
Stock-based compensation	1,695		717
Other	186		162
Total deferred tax assets:	30,316		17,182
Deferred income tax liabilities
Right-of-use assets	2,261		2,132
Other	287		157
Total deferred tax liabilities	2,548		2,289
Net deferred income tax assets	27,768		14,893
Less: valuation allowance	(27,768)		(14,893)
Deferred tax assets, net of valuation allowance	$	—	$	—