Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Non-Voting Convertible Preferred Stock	Common Stock	Additional Paid-In Capital	Additional Paid-In Capital Non-Voting Convertible Preferred Stock	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2018			23,537,368
Beginning balance at Dec. 31, 2018	$ 72,672			$ 302,759		$ (230,087)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock and convertible preferred stock for Former Neoleukin common stock (in shares)		102,000	4,589,771
Issuance of common stock and convertible preferred stock for Former Neoleukin common stock	15,055	$ 33,432		15,055	$ 33,432
Conversion of convertible preferred stock into common shares (in shares)		(102,000)	10,192,700
Issuance of common stock, net of discounts, commissions and offering expenses (in shares)			10,263,750
Issuance of common stock, net of discounts, commissions and offering expenses	80,691			80,691
Issuance of common stock to University of Washington (in shares)			12,647
Issuance of common stock to University of Washington	41			41
Conversion of common stock to pre-funded warrants (in shares)			(10,925,481)
Options exercised (in shares)			326,094
Options exercised	1,555			1,555
Stock-based compensation	7,683			7,683
Net loss	(69,442)					(69,442)
Ending balance (in shares) at Dec. 31, 2019			37,996,849
Ending balance at Dec. 31, 2019	141,687			441,216		(299,529)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock, net of discounts, commissions and offering expenses (in shares)			3,262,471
Issuance of common stock, net of discounts, commissions and offering expenses	$ 71,320			71,320
Options exercised (in shares)	882,624		882,624
Options exercised	$ 5,665			5,665
Restricted stock units vested (in shares)			36,000
Issuance of common stock under Employee Stock Purchase Plan (in shares)	18,352		18,352
Issuance of common stock under Employee Stock Purchase Plan	$ 199			199
Stock-based compensation	5,622			5,622
Net loss	(33,277)					(33,277)
Ending balance (in shares) at Dec. 31, 2020			42,196,296
Ending balance at Dec. 31, 2020	$ 191,216			$ 524,022		$ (332,806)