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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Pay vs Performance Disclosure      
Pay vs Performance Disclosure, Table
Year
Summary Compensation Table Total for Dr. McMinn1
Compensation Actually Paid to Dr. McMinn2
Summary Compensation Table Total for Ms. Cochener1
Compensation Actually Paid to Ms. Cochener2
Summary Compensation Table Total for Dr. Drachman1
Compensation Actually Paid to Dr. Drachman2
Average Summary Compensation Table Total for Non-Principal Executive Officer (“PEO”) NEOs3
Average Compensation Actually Paid to Non-PEO NEOs4
Value of Initial Fixed $100 Investment Based On Total Shareholder Return (“TSR”)5
Net Income (Loss)6 (in thousands)
20243,464,815 2,723,448 — — — — 2,911,105 2,361,984 24 (75,144)
20231,080,629 1,041,892 1,827,432 1,902,501 549,983 477,211 1,242,197 1,252,222 20 (36,317)
2022––––––––902,179 (3,599,400)1,027,439 (119,619)11 (60,692)
    
Named Executive Officers, Footnote The dollar amounts reported are the amounts of total compensation reported in our Summary Compensation Table. The dollar amounts reported represent the average of the amounts reported for the Company’s NEOs as a group (excluding the PEO(s)) in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the NEOs (excluding the PEO(s)) included for purposes of calculating the average amounts in each applicable year are as follows: (i) for 2024, Ms. Mikail and Dr. Jordan, (ii) for 2023, Ms. Mikail, Dr. Cobb, and the Company’s former Interim Chief Financial Officer Sean Smith; and (iii) for 2022, Ms. Cochener and the Company’s former Chief Medical Officer, Priti Patel.    
Peer Group Issuers, Footnote Cumulative TSR is calculated by dividing the sum of the cumulative amount of dividends, if any, for the measurement period, assuming dividend reinvestment, and the difference between the Company’s stock price at the end and the beginning of the measurement period by the Company’s stock price at the beginning of the measurement period. The beginning of the measurement period for each year in the table is December 31, 2021.    
Adjustment To PEO Compensation, Footnote The dollar amounts reported represent the amount of “compensation actually paid” to each of the PEOs during the applicable year, as computed in accordance with SEC rules. The dollar amounts do not reflect the actual amount of compensation earned by or paid to the PEOs during the applicable year. In accordance with SEC rules, these amounts reflect “Total Compensation” as set forth in the Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant.
Compensation Actually Paid to PEO
2024
(Dr. McMinn)
Summary Compensation Table Total3,464,815 
Less, value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table
(2,535,405)
Plus, year-end fair value of outstanding and unvested equity awards granted in the year1,500,082 
Plus (less), year over year change in fair value of outstanding and unvested equity awards granted in prior years30,078 
Plus (less), change in fair value from prior year end to the vesting date of equity awards granted in prior years that vested in the year
263,878 
Less, prior year-end fair value for any equity awards forfeited in the year— 
Compensation Actually Paid to PEO2,723,448 
    
Non-PEO NEO Average Total Compensation Amount $ 2,911,105 $ 1,242,197 $ 1,027,439
Non-PEO NEO Average Compensation Actually Paid Amount $ 2,361,984 1,252,222 (119,619)
Adjustment to Non-PEO NEO Compensation Footnote The dollar amounts reported represent the average amount of “compensation actually paid” to the NEOs as a group (excluding the PEO(s)), as computed in accordance with SEC rules. The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding the PEO(s)) during the applicable year. In accordance with the SEC rules, these amounts reflect “Total” as set forth in the Summary Compensation Table for each year, adjusted as shown below. Equity values are calculated in accordance with FASB ASC Topic 718, and the valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of the grant.
Average Compensation Actually Paid to Non-PEO NEOs2024
Average Summary Compensation Table Total2,911,105 
Less, average value of “Option Awards” and “Stock Awards” reported in Summary Compensation Table
(2,212,212)
Plus, average year-end fair value of outstanding and unvested equity awards granted in the year1,411,703 
Plus, average fair value as of vesting date of equity awards granted and vested in the year— 
Plus (less), average year over year change in fair value of outstanding and unvested equity awards granted in prior years46,846 
Plus (less), average change in fair value from the prior year end to the vesting date of equity awards granted in prior years that vested in the year
204,542 
Less, prior year-end fair value for any equity awards forfeited in the year— 
Average Compensation Actually Paid to Non-PEO NEOs
2,361,984 
    
Compensation Actually Paid vs. Total Shareholder Return
The following chart sets forth the relationship between Compensation Actually Paid to our PEO(s), the average of Compensation Actually Paid to our non-PEO NEOs, and the Company’s TSR over the fiscal three year period from 2022 through 2024:

Relationship Between NEO comp actually paid and company TSR.jpg
    
Compensation Actually Paid vs. Net Income
The following chart sets forth the relationship between Compensation Actually Paid to our PEO(s), the average of Compensation Actually Paid to our Non-PEO NEOs, and the Company’s Net Income (Loss) over the three fiscal year period from 2022 through 2024:
Relationship Between NEO comp actually paid and net loss.jpg
    
Total Shareholder Return Amount $ 24 20 11
Net Income (Loss) $ (75,144,000) (36,317,000) (60,692,000)
Additional 402(v) Disclosure The dollar amounts reported represent the amount of net income (loss) reflected in the Company’s audited financial statements for the applicable year.    
Dr. McMinn [Member]      
Pay vs Performance Disclosure      
PEO Total Compensation Amount $ 3,464,815 1,080,629  
PEO Actually Paid Compensation Amount 2,723,448 1,041,892  
Ms. Cochener [Member]      
Pay vs Performance Disclosure      
PEO Total Compensation Amount 0 1,827,432  
PEO Actually Paid Compensation Amount 0 1,902,501  
Dr. Drachman [Member]      
Pay vs Performance Disclosure      
PEO Total Compensation Amount 0 549,983 902,179
PEO Actually Paid Compensation Amount 0 $ 477,211 $ (3,599,400)
PEO | Dr. McMinn [Member] | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (2,535,405)    
PEO | Dr. McMinn [Member] | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,500,082    
PEO | Dr. McMinn [Member] | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 30,078    
PEO | Dr. McMinn [Member] | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 263,878    
PEO | Dr. McMinn [Member] | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount (2,212,212)    
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 1,411,703    
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 46,846    
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 0    
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount 204,542    
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year      
Pay vs Performance Disclosure      
Adjustment to Compensation, Amount $ 0