Income Taxes - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Tax Credit Carryforward [Line Items]
Valuation allowance, deferred tax asset, increase (decrease), amount	$ 16,000,000.0	$ 60,700,000
Unrecognized tax benefits that would impact effective tax rate	3,400,000	2,600,000
Domestic Tax Jurisdiction
Tax Credit Carryforward [Line Items]
Income tax expense (benefit)	0	0
Operating loss carryforwards	319,800,000	277,900,000
Domestic Tax Jurisdiction | Research Tax Credit Carryforward
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	7,900,000	7,500,000
Domestic Tax Jurisdiction | Federal Orphan Drug Tax Credit Carryforward
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	4,800,000
Domestic Tax Jurisdiction | Subject To Expiration
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	2,300,000
Domestic Tax Jurisdiction | Carried Forward Indefinitely
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	317,500,000
State and Local Jurisdiction
Tax Credit Carryforward [Line Items]
Income tax expense (benefit)	0	0
Operating loss carryforwards	39,600,000	$ 35,100,000
State and Local Jurisdiction | Research Tax Credit Carryforward
Tax Credit Carryforward [Line Items]
Tax credit carryforward, amount	200,000
State and Local Jurisdiction | Subject To Expiration
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	37,700,000
State and Local Jurisdiction | Carried Forward Indefinitely
Tax Credit Carryforward [Line Items]
Operating loss carryforwards	$ 1,900,000