Restructuring (Tables)

12 Months Ended

Dec. 31, 2019

Restructuring Plan, July 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability related to the July 2018 restructuring as at December 31, 2019: 

(in thousands)	CLINICAL TRIAL CLOSING COSTS			ONE-TIME EMPLOYEE TERMINATION BENEFITS			CONTRACT TERMINATION COSTS			SAN BRUNO OFFICE CLOSING COSTS			TOTAL EXPENSES
Amounts accrued as at January 1, 2018	$	—		$	—		$	—		$	—		$	—
Charges—July 2018		5,703			1,879			1,108			465			9,155
Revised estimates during 2018		41			2			187			5			235
Total restructuring costs expected to be incurred		5,744			1,881			1,295			470			9,390
Amounts paid during 2018		(2,204	)		(1,881	)		(1,201	)		(470	)		(5,756	)
Amounts accrued at December 31, 2018		3,540			—			94			—			3,634
Revised estimates during 2019		(1,957	)		—			12			—			(1,945	)
Amounts paid during 2019		(1,583	)		—			(106	)		—			(1,689	)
Amounts accrued at December 31, 2019	$	—		$	—		$	—		$	—		$	—

Restructuring Plan, November 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability related to the November 2018 restructuring as at December 31, 2019:

(in thousands)	ONE-TIME EMPLOYEE TERMINATION BENEFITS
Total restructuring costs expected to be incurred	$	984
Amount paid in 2018		(922	)
Amount accrued at December 31, 2018		62
Restructuring costs incurred during 2019		655
Amount paid during the period ended December 31, 2019		(702	)
Amount accrued at December 31, 2019	$	15
Restructuring charges expected to be incurred		1,645
Cumulative restructuring costs incurred as at December 31, 2019		(1,639	)
Restructuring charges expected to be incurred in future periods	$	6