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Property and equipment, net
 12 Months Ended
Dec. 31, 2019
Property, Plant and Equipment [Abstract]  
Property and equipment, net
 
4
. Property and equipment, net
 
   
DECEMBER 31, 2019
 
(in thousands)
  
COST
   
ACCUMULATED
AMORTIZATION
   
NET BOOK
VALUE
 
Leasehold improvements
  $490   $333   $157 
Laboratory equipment
   1,515    62    1,453 
Office furniture, equipment and systems
   743    293    450 
  
 
 
   
 
 
   
 
 
 
  $2,748   $688   $2,060 
  
 
 
   
 
 
   
 
 
 
 
   
DECEMBER 31, 2018
 
(in thousands)
  
COST
   
ACCUMULATED
AMORTIZATION
   
NET BOOK 
VALUE
 
Leasehold improvements
  $490   $248   $242 
Office furniture, equipment and systems
   353    195    158 
  
 
 
   
 
 
   
 
 
 
  $843   $443   $400 
  
 
 
   
 
 
   
 
 
 
Depreciation expense on property and equipment totaled $0.2 million, $0.3 million and $0.4 million for the years ended December 31, 2019, 2018 and 2017, respectively.