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+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130543-203045

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130545-203045

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+ References

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License and patent agreements - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended	9 Months Ended		12 Months Ended
	Sep. 30, 2019	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2018
License and patent agreements [Line Items]
Cumulative net sales of licensed products			$ 25,000	$ 25,000
Common Stock [Member]
License and patent agreements [Line Items]
Stock issued for acquisition	4,589,771	4,589,771
License and Maintenance [Member] \| University Of Washington [Member]
License and patent agreements [Line Items]
Shares issued for service	536,813
Shares issued percentage	5.00%	5.00%
License and Maintenance [Member] \| University Of Washington [Member] \| First Milestone Payment [Member]
License and patent agreements [Line Items]
Amount of development milestones payment	$ 900	$ 900
License and Maintenance [Member] \| University Of Washington [Member] \| Second Milestone Payment [Member]
License and patent agreements [Line Items]
Amount of development milestones payment	$ 10,000	$ 10,000
License and Maintenance [Member] \| Common Stock [Member] \| University Of Washington [Member]
License and patent agreements [Line Items]
Stock issued for acquisition	188,974
License and Maintenance [Member] \| Minimum [Member] \| University Of Washington [Member]
License and patent agreements [Line Items]
Shares issued percentage	5.00%	5.00%
Cumulative net sales of licensed products	$ 100,000
License and Maintenance [Member] \| Maximum [Member] \| University Of Washington [Member]
License and patent agreements [Line Items]
Cumulative net sales of licensed products	$ 1,000,000
Non-voting convertible preferred stock [Member] \| License and Maintenance [Member] \| University Of Washington [Member]
License and patent agreements [Line Items]
Stock issued for acquisition	4,197