Previous license and collaboration agreement - Additional Information (Detail) - USD ($) $ in Thousands	9 Months Ended	12 Months Ended
Sep. 30, 2018	Dec. 31, 2018
Agreement Terms		The license and collaboration agreement also included an upfront payment of $25.0 million and contractual milestones.
Revenue	$ 25,000	$ 25,000
Non Refundable Up Front Payment Received		25,000
Astellas US LLC [Member]
Revenue		$ 25,000

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 4
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130543-203045

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=118956577&loc=SL49130545-203045

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Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration