Restructuring (Tables)

6 Months Ended

Jun. 30, 2019

Restructuring Plan, July 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amounts incurred and the liability accrued related to the July 2018 restructuring as at June 30, 2019:

(in thousands)	CLINICAL TRIAL CLOSING COSTS			ONE-TIME EMPLOYEE TERMINATION BENEFITS			CONTRACT TERMINATION COSTS			SAN BRUNO OFFICE CLOSING COSTS			TOTAL EXPENSES
Amounts accrued as at January 1, 2018	$	—		$	—		$	—		$	—		$	—
Charges for the year		5,703			1,879			1,108			465			9,155
Revised estimates during the year		41			2			187			5			235
Total restructuring costs expected to be incurred		5,744			1,881			1,295			470			9,390
Amounts paid during the year		(2,204	)		(1,881	)		(1,201	)		(470	)		(5,756	)
Amounts accrued as at December 31, 2018		3,540			—			94			—			3,634
Revised estimates during the period		(1,935	)		—			(16	)		—			(1,951	)
Amounts paid during the period		(1,552	)		—			(78	)		—			(1,630	)
Amounts accrued as at June 30, 2019	$	53		$	—		$	—		$	—		$	53

Restructuring Plan, November 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability related to the November 2018 restructuring as at June 30, 2019:

(in thousands)	ONE-TIME EMPLOYEE TERMINATION BENEFITS
Total restructuring costs incurred in 2018	$	984
Amount paid in 2018		(922	)
Amount accrued at December 31, 2018		62
Restructuring costs expected to be incurred in 2019		663
Amount paid during the period ended June 30, 2019		(254	)
Amount accrued at June 30, 2019		(303	)
Amount expected to be incurred in future periods	$	168