Restructuring (Tables)

9 Months Ended

Sep. 30, 2018

Restructuring and Related Activities [Abstract]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability as at September 30, 2018:

(in thousands)	Total expenses
Clinical trial closing costs	$	5,703
One-time employee termination benefits		1,879
Contract termination costs		1,108
San Bruno office closing costs		465
Total restructuring costs expected to be incurred		9,155
Amounts to be incurred in the fourth quarter		(184	)
Amounts paid during the period		(3,340	)
Amounts accrued at September 30, 2018	$	5,631