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Common stock - Schedule of Weighted Average Assumptions (Detail) - $ / shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]      
Expected volatility 97.00% 108.00% 94.00%
Expected dividends 0.00% 0.00% 0.00%
Expected terms (years) 6 years 6 years 6 years 3 months
Risk free rate 1.48% 1.67% 2.11%
Weighted average grant-date fair value of stock options $ 8.91 $ 8.19 $ 0.40