<informationTable xmlns="http://www.sec.gov/edgar/document/thirteenf/informationtable">		<infoTable>
			<nameOfIssuer>ADIENT PLC</nameOfIssuer>
			<titleOfClass>ORD SHS</titleOfClass>
			<cusip>G0084W101</cusip>
			<value>20859</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1203588</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1203588</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ADMA BIOLOGICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>000899104</cusip>
			<value>4780</value>
			<shrsOrPrnAmt>
				<sshPrnamt>2000000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>2000000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>AFFIMED N V</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>N01045108</cusip>
			<value>12373</value>
			<shrsOrPrnAmt>
				<sshPrnamt>3650000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>3650000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ALDEYRA THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>01438T106</cusip>
			<value>1223</value>
			<shrsOrPrnAmt>
				<sshPrnamt>165000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>165000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ALNYLAM PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>02043Q107</cusip>
			<value>15288</value>
			<shrsOrPrnAmt>
				<sshPrnamt>105000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>105000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ALTRIA GROUP INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>02209S103</cusip>
			<value>17537</value>
			<shrsOrPrnAmt>
				<sshPrnamt>453860</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>453860</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>AMAZON COM INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>023135106</cusip>
			<value>37785</value>
			<shrsOrPrnAmt>
				<sshPrnamt>12000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>12000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>AMCI ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 05/20/202</titleOfClass>
			<cusip>00165R119</cusip>
			<value>136</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ANGI HOMESERVICES INC</nameOfIssuer>
			<titleOfClass>COM CL A</titleOfClass>
			<cusip>00183L102</cusip>
			<value>12756</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1149673</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1149673</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>APPLIED GENETIC TECHNOLOGIES</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>03820J100</cusip>
			<value>1770</value>
			<shrsOrPrnAmt>
				<sshPrnamt>364299</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>364299</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>APTOSE BIOSCIENCES INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>03835T200</cusip>
			<value>7001</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1166887</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1166887</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ARCTURUS THERAPEUTICS HLDGS</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>03969T109</cusip>
			<value>723</value>
			<shrsOrPrnAmt>
				<sshPrnamt>16855</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>16855</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ARDELYX INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>039697107</cusip>
			<value>11911</value>
			<shrsOrPrnAmt>
				<sshPrnamt>2268798</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>2268798</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ARYA SCIENCES ACQUISITION CO</nameOfIssuer>
			<titleOfClass>COM CL A</titleOfClass>
			<cusip>G3166W106</cusip>
			<value>4326</value>
			<shrsOrPrnAmt>
				<sshPrnamt>400000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>400000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>AT HOME GROUP INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>04650Y100</cusip>
			<value>6104</value>
			<shrsOrPrnAmt>
				<sshPrnamt>410793</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>410793</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ATARA BIOTHERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>046513107</cusip>
			<value>2862</value>
			<shrsOrPrnAmt>
				<sshPrnamt>220848</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>220848</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BARRICK GOLD CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>067901108</cusip>
			<value>15783</value>
			<shrsOrPrnAmt>
				<sshPrnamt>561477</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>561477</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BERKSHIRE HATHAWAY INC DEL</nameOfIssuer>
			<titleOfClass>CL B NEW</titleOfClass>
			<cusip>084670702</cusip>
			<value>10647</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BIG ROCK PARTNERS ACQUISI CO</nameOfIssuer>
			<titleOfClass>*W EXP 12/01/202</titleOfClass>
			<cusip>089482111</cusip>
			<value>21</value>
			<shrsOrPrnAmt>
				<sshPrnamt>82500</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>82500</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BIG ROCK PARTNERS ACQUISI CO</nameOfIssuer>
			<titleOfClass>RIGHT 12/01/2022</titleOfClass>
			<cusip>089482129</cusip>
			<value>34</value>
			<shrsOrPrnAmt>
				<sshPrnamt>165000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>165000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BIOMX INC</nameOfIssuer>
			<titleOfClass>*W EXP 10/16/202</titleOfClass>
			<cusip>09090D111</cusip>
			<value>59</value>
			<shrsOrPrnAmt>
				<sshPrnamt>83084</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>83084</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BONANZA CREEK ENERGY INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>097793400</cusip>
			<value>235</value>
			<shrsOrPrnAmt>
				<sshPrnamt>12500</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>12500</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>BROOGE ENERGY LTD</nameOfIssuer>
			<titleOfClass>*W EXP 12/20/202</titleOfClass>
			<cusip>G1611B115</cusip>
			<value>161</value>
			<shrsOrPrnAmt>
				<sshPrnamt>321684</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>321684</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CAPITAL ONE FINL CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>14040H105</cusip>
			<value>35328</value>
			<shrsOrPrnAmt>
				<sshPrnamt>491617</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>491617</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CARDLYTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>14161W105</cusip>
			<value>70625</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1000774</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1000774</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CARVANA CO</nameOfIssuer>
			<titleOfClass>CL A</titleOfClass>
			<cusip>146869102</cusip>
			<value>167294</value>
			<shrsOrPrnAmt>
				<sshPrnamt>750000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>750000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CELLECTIS S A</nameOfIssuer>
			<titleOfClass>SPON ADS</titleOfClass>
			<cusip>15117K103</cusip>
			<value>3701</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ARYA SCIENCES ACQUISITION CO</nameOfIssuer>
			<titleOfClass>*W EXP 06/09/202</titleOfClass>
			<cusip>G31655106</cusip>
			<value>421</value>
			<shrsOrPrnAmt>
				<sshPrnamt>233333</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>233333</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ARYA SCIENCES ACQUISITION CO</nameOfIssuer>
			<titleOfClass>COM CL A</titleOfClass>
			<cusip>G31655122</cusip>
			<value>7315</value>
			<shrsOrPrnAmt>
				<sshPrnamt>700000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>700000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CHIMERIX INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>16934W106</cusip>
			<value>822</value>
			<shrsOrPrnAmt>
				<sshPrnamt>330061</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>330061</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CIMPRESS PLC</nameOfIssuer>
			<titleOfClass>SHS EURO</titleOfClass>
			<cusip>G2143T103</cusip>
			<value>6572</value>
			<shrsOrPrnAmt>
				<sshPrnamt>87436</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>87436</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CM LIFE SCIENCES INC</nameOfIssuer>
			<titleOfClass>UNIT 09/01/2025</titleOfClass>
			<cusip>18978W208</cusip>
			<value>7853</value>
			<shrsOrPrnAmt>
				<sshPrnamt>750000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>750000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>COCA-COLA CO</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>191216100</cusip>
			<value>9874</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CONTRAFECT CORP</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>212326300</cusip>
			<value>3168</value>
			<shrsOrPrnAmt>
				<sshPrnamt>600000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>600000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CRESUD S A C I F Y A</nameOfIssuer>
			<titleOfClass>SPONSORED ADR</titleOfClass>
			<cusip>226406106</cusip>
			<value>3876</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1379039</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1379039</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>CUE BIOPHARMA INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>22978P106</cusip>
			<value>4816</value>
			<shrsOrPrnAmt>
				<sshPrnamt>320000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>320000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>DHT HOLDINGS INC</nameOfIssuer>
			<titleOfClass>SHS NEW</titleOfClass>
			<cusip>Y2065G121</cusip>
			<value>7307</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1416100</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
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			<nameOfIssuer>DIAGEO PLC</nameOfIssuer>
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				<sshPrnamt>218000</sshPrnamt>
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			<nameOfIssuer>DIAMOND S SHIPPING INC</nameOfIssuer>
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			<nameOfIssuer>DIANA SHIPPING INC</nameOfIssuer>
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			<nameOfIssuer>DIRTT ENVIRONMENTAL SOLUTION</nameOfIssuer>
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			<nameOfIssuer>EIGER BIOPHARMACEUTICALS INC</nameOfIssuer>
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			<cusip>28249U105</cusip>
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			<nameOfIssuer>ENERGY RECOVERY INC</nameOfIssuer>
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			<nameOfIssuer>ENOVA INTL INC</nameOfIssuer>
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			<nameOfIssuer>EURONAV NV</nameOfIssuer>
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			<investmentDiscretion>DFND</investmentDiscretion>
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			<nameOfIssuer>FALCON MINERALS CORP</nameOfIssuer>
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			<nameOfIssuer>FATE THERAPEUTICS INC</nameOfIssuer>
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			<nameOfIssuer>FENNEC PHARMACEUTICALS INC</nameOfIssuer>
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			<nameOfIssuer>FIRSTENERGY CORP</nameOfIssuer>
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			<nameOfIssuer>FORTRESS BIOTECH INC</nameOfIssuer>
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			<nameOfIssuer>FRONTLINE LTD</nameOfIssuer>
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			<nameOfIssuer>GENCO SHIPPING &amp; TRADING LTD</nameOfIssuer>
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			<nameOfIssuer>GENERAL MTRS CO</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
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			<nameOfIssuer>GLOBALSTAR INC</nameOfIssuer>
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			<nameOfIssuer>GLOBALSTAR INC</nameOfIssuer>
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			<nameOfIssuer>GLRY STR NW MDIA GRUP HLDG L</nameOfIssuer>
			<titleOfClass>*W EXP 02/13/202</titleOfClass>
			<cusip>G39973113</cusip>
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			<investmentDiscretion>DFND</investmentDiscretion>
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			<nameOfIssuer>GOLAR LNG PARTNERS LP</nameOfIssuer>
			<titleOfClass>COM UNIT LPI</titleOfClass>
			<cusip>Y2745C102</cusip>
			<value>1957</value>
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			<investmentDiscretion>DFND</investmentDiscretion>
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			<nameOfIssuer>GREIF INC</nameOfIssuer>
			<titleOfClass>CL B</titleOfClass>
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			<investmentDiscretion>DFND</investmentDiscretion>
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			<nameOfIssuer>GRUBHUB INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
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			<nameOfIssuer>GSX TECHEDU INC</nameOfIssuer>
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			<nameOfIssuer>HEALTH SCIENCES ACQ CORP 2</nameOfIssuer>
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			<nameOfIssuer>HERTZ GLOBAL HLDGS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
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			<nameOfIssuer>HERTZ GLOBAL HLDGS INC</nameOfIssuer>
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		<infoTable>
			<nameOfIssuer>HL ACQUISITIONS CORP</nameOfIssuer>
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			<cusip>G4603R122</cusip>
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			<nameOfIssuer>HL ACQUISITIONS CORP</nameOfIssuer>
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			<nameOfIssuer>HOSTESS BRANDS INC</nameOfIssuer>
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			<nameOfIssuer>HYCROFT MINING HOLDING CORP</nameOfIssuer>
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			<nameOfIssuer>HYCROFT MINING HOLDING CORP</nameOfIssuer>
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			<cusip>44862P117</cusip>
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			<nameOfIssuer>IAC INTERACTIVECORP NEW</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
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			<nameOfIssuer>IAMGOLD CORP</nameOfIssuer>
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			<cusip>450913108</cusip>
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		<infoTable>
			<nameOfIssuer>IMMATICS N.V.</nameOfIssuer>
			<titleOfClass>SHS</titleOfClass>
			<cusip>N44445109</cusip>
			<value>11141</value>
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		<infoTable>
			<nameOfIssuer>IMMATICS N.V.</nameOfIssuer>
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			<cusip>N44445117</cusip>
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			<investmentDiscretion>DFND</investmentDiscretion>
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		<infoTable>
			<nameOfIssuer>IMMUNOMEDICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
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			<investmentDiscretion>DFND</investmentDiscretion>
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		<infoTable>
			<nameOfIssuer>INSPIRED ENTMT INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>45782N108</cusip>
			<value>2416</value>
			<shrsOrPrnAmt>
				<sshPrnamt>816325</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>816325</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>INTL GNRL INSURANCE HLDNGS L</nameOfIssuer>
			<titleOfClass>*W EXP 03/17/202</titleOfClass>
			<cusip>G4809J114</cusip>
			<value>269</value>
			<shrsOrPrnAmt>
				<sshPrnamt>450000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>450000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>IOVANCE BIOTHERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>462260100</cusip>
			<value>3292</value>
			<shrsOrPrnAmt>
				<sshPrnamt>100000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>100000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>IRSA INVERSIONES Y REP S A</nameOfIssuer>
			<titleOfClass>GLOBL DEP RCPT</titleOfClass>
			<cusip>450047204</cusip>
			<value>2757</value>
			<shrsOrPrnAmt>
				<sshPrnamt>977759</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>977759</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>IRSA PROPIEDADES COMERCIALES</nameOfIssuer>
			<titleOfClass>SPONSORED ADR</titleOfClass>
			<cusip>463588103</cusip>
			<value>3355</value>
			<shrsOrPrnAmt>
				<sshPrnamt>432165</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>432165</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ISHARES TR</nameOfIssuer>
			<titleOfClass>JPMORGAN USD EMG</titleOfClass>
			<cusip>464288281</cusip>
			<value>66534</value>
			<shrsOrPrnAmt>
				<sshPrnamt>600000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>600000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>JPMORGAN CHASE &amp; CO</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>46625H100</cusip>
			<value>3369</value>
			<shrsOrPrnAmt>
				<sshPrnamt>35000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>35000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>KADMON HLDGS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>48283N106</cusip>
			<value>666</value>
			<shrsOrPrnAmt>
				<sshPrnamt>170000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>170000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>KALEYRA INC</nameOfIssuer>
			<titleOfClass>*W EXP 12/12/202</titleOfClass>
			<cusip>483379111</cusip>
			<value>130</value>
			<shrsOrPrnAmt>
				<sshPrnamt>91791</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>91791</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>KROGER CO</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>501044101</cusip>
			<value>3391</value>
			<shrsOrPrnAmt>
				<sshPrnamt>100000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<putCall>Call</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>100000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>LARIMAR THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>517125100</cusip>
			<value>3339</value>
			<shrsOrPrnAmt>
				<sshPrnamt>220136</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>220136</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>LEAP THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>52187K101</cusip>
			<value>1042</value>
			<shrsOrPrnAmt>
				<sshPrnamt>526466</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>526466</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>LEGACY ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 11/30/202</titleOfClass>
			<cusip>524643111</cusip>
			<value>268</value>
			<shrsOrPrnAmt>
				<sshPrnamt>500000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>500000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>LEISURE ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 12/05/201</titleOfClass>
			<cusip>52539T115</cusip>
			<value>59</value>
			<shrsOrPrnAmt>
				<sshPrnamt>125000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>125000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>LF CAP ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 06/22/202</titleOfClass>
			<cusip>50200K116</cusip>
			<value>810</value>
			<shrsOrPrnAmt>
				<sshPrnamt>450000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>450000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MAGELLAN MIDSTREAM PRTNRS LP</nameOfIssuer>
			<titleOfClass>COM UNIT RP LP</titleOfClass>
			<cusip>559080106</cusip>
			<value>49957</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1460732</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1460732</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MAIDEN HOLDINGS LTD</nameOfIssuer>
			<titleOfClass>SHS</titleOfClass>
			<cusip>G5753U112</cusip>
			<value>9610</value>
			<shrsOrPrnAmt>
				<sshPrnamt>7876964</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>7876964</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MARINUS PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>56854Q200</cusip>
			<value>12486</value>
			<shrsOrPrnAmt>
				<sshPrnamt>971718</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>971718</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MEGALITH FINL ACQUISITION CO</nameOfIssuer>
			<titleOfClass>*W EXP 08/26/202</titleOfClass>
			<cusip>58518F117</cusip>
			<value>266</value>
			<shrsOrPrnAmt>
				<sshPrnamt>400000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>400000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MEGALITH FINL ACQUISITION CO</nameOfIssuer>
			<titleOfClass>CL A COM</titleOfClass>
			<cusip>58518F109</cusip>
			<value>105</value>
			<shrsOrPrnAmt>
				<sshPrnamt>10133</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>10133</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MEIRAGTX HOLDINGS PLC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>G59665102</cusip>
			<value>9063</value>
			<shrsOrPrnAmt>
				<sshPrnamt>684447</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>684447</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>METEN EDTECHX ED GROUP LTD</nameOfIssuer>
			<titleOfClass>*W EXP 03/31/202</titleOfClass>
			<cusip>G6055H106</cusip>
			<value>26</value>
			<shrsOrPrnAmt>
				<sshPrnamt>125000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>125000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>MUSTANG BIO INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>62818Q104</cusip>
			<value>1449</value>
			<shrsOrPrnAmt>
				<sshPrnamt>460000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>460000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>NATIONAL ENERGY SERVICES REU</nameOfIssuer>
			<titleOfClass>*W EXP 05/05/202</titleOfClass>
			<cusip>G6375R115</cusip>
			<value>507</value>
			<shrsOrPrnAmt>
				<sshPrnamt>723700</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
			</shrsOrPrnAmt>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>723700</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>NAVIOS MARITIME CONTAINERS L</nameOfIssuer>
			<titleOfClass>COM UNIT RP LP</titleOfClass>
			<cusip>Y62151108</cusip>
			<value>2318</value>
			<shrsOrPrnAmt>
				<sshPrnamt>2235000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>2235000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>NIKOLA CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>654110105</cusip>
			<value>3972</value>
			<shrsOrPrnAmt>
				<sshPrnamt>193900</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Call</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>193900</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>NUVEEN NEW YORK AMT QLT MUNI</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>670656107</cusip>
			<value>185</value>
			<shrsOrPrnAmt>
				<sshPrnamt>14400</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>14400</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ON DECK CAP INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>682163100</cusip>
			<value>9269</value>
			<shrsOrPrnAmt>
				<sshPrnamt>5793015</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>5793015</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ONCOSEC MED INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>68234L306</cusip>
			<value>270</value>
			<shrsOrPrnAmt>
				<sshPrnamt>79935</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>79935</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ORISUN ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>68632T109</cusip>
			<value>509</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ORISUN ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>RIGHT 05/31/2024</titleOfClass>
			<cusip>68632T125</cusip>
			<value>30</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>ORISUN ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 05/31/202</titleOfClass>
			<cusip>68632T117</cusip>
			<value>15</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>OTONOMY INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>68906L105</cusip>
			<value>3645</value>
			<shrsOrPrnAmt>
				<sshPrnamt>900000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>900000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PANACEA ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 07/07/202</titleOfClass>
			<cusip>698102118</cusip>
			<value>470</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PANACEA ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>CL A</titleOfClass>
			<cusip>698102100</cusip>
			<value>6719</value>
			<shrsOrPrnAmt>
				<sshPrnamt>600000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>600000</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PBF LOGISTICS LP</nameOfIssuer>
			<titleOfClass>UNIT LTD PTNR</titleOfClass>
			<cusip>69318Q104</cusip>
			<value>128</value>
			<shrsOrPrnAmt>
				<sshPrnamt>15663</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>15663</Sole>
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				<None>0</None>
			</votingAuthority>
		</infoTable>
		<infoTable>
			<nameOfIssuer>PENN VA CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>70788V102</cusip>
			<value>8714</value>
			<shrsOrPrnAmt>
				<sshPrnamt>884603</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>884603</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PG&amp;E CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>69331C108</cusip>
			<value>33653</value>
			<shrsOrPrnAmt>
				<sshPrnamt>3583929</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
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				<Sole>3583929</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PG&amp;E CORP</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>69331C108</cusip>
			<value>470</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Call</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PIERIS PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>720795103</cusip>
			<value>186</value>
			<shrsOrPrnAmt>
				<sshPrnamt>90000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>90000</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PROSHARES TR II</nameOfIssuer>
			<titleOfClass>ULTA BLMBG 2017</titleOfClass>
			<cusip>74347Y888</cusip>
			<value>5690</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>PROVENTION BIO INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>74374N102</cusip>
			<value>11025</value>
			<shrsOrPrnAmt>
				<sshPrnamt>859314</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>859314</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>ROTH CH ACQUISITION I CO</nameOfIssuer>
			<titleOfClass>*W EXP 01/28/202</titleOfClass>
			<cusip>778675116</cusip>
			<value>143</value>
			<shrsOrPrnAmt>
				<sshPrnamt>138750</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>138750</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>ROTH CH ACQUISITION I CO</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>778675108</cusip>
			<value>1841</value>
			<shrsOrPrnAmt>
				<sshPrnamt>185000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>185000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>SCHULTZE SPL PURP ACQUSTN CO</nameOfIssuer>
			<titleOfClass>*W EXP 12/31/202</titleOfClass>
			<cusip>80821R117</cusip>
			<value>156</value>
			<shrsOrPrnAmt>
				<sshPrnamt>300000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>300000</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>SELECTA BIOSCIENCES INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>816212104</cusip>
			<value>1772</value>
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				<sshPrnamt>714619</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>714619</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		<infoTable>
			<nameOfIssuer>SIERRA ONCOLOGY INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>82640U404</cusip>
			<value>1495</value>
			<shrsOrPrnAmt>
				<sshPrnamt>140156</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>140156</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>STRONGBRIDGE BIOPHARMA PLC</nameOfIssuer>
			<titleOfClass>SHS USD</titleOfClass>
			<cusip>G85347105</cusip>
			<value>3350</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1595082</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1595082</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>SYNDAX PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>87164F105</cusip>
			<value>12227</value>
			<shrsOrPrnAmt>
				<sshPrnamt>828371</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>828371</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TEEKAY TANKERS LTD</nameOfIssuer>
			<titleOfClass>CL A</titleOfClass>
			<cusip>Y8565N300</cusip>
			<value>955</value>
			<shrsOrPrnAmt>
				<sshPrnamt>88124</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>88124</Sole>
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				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>TENZING ACQUISITION CORP</nameOfIssuer>
			<titleOfClass>*W EXP 02/23/202</titleOfClass>
			<cusip>G8708A108</cusip>
			<value>102</value>
			<shrsOrPrnAmt>
				<sshPrnamt>200000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>200000</Sole>
				<Shared>0</Shared>
				<None>0</None>
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		</infoTable>
		<infoTable>
			<nameOfIssuer>TESLA INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>88160R101</cusip>
			<value>10725</value>
			<shrsOrPrnAmt>
				<sshPrnamt>25000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Call</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>25000</Sole>
				<Shared>0</Shared>
				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>TESLA INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>88160R101</cusip>
			<value>21451</value>
			<shrsOrPrnAmt>
				<sshPrnamt>50000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>50000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TFF PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>87241J104</cusip>
			<value>2173</value>
			<shrsOrPrnAmt>
				<sshPrnamt>117647</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>117647</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TG THERAPEUTICS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>88322Q108</cusip>
			<value>10658</value>
			<shrsOrPrnAmt>
				<sshPrnamt>398271</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>398271</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TOTTENHAM ACQUISITION I LTD</nameOfIssuer>
			<titleOfClass>*W EXP 05/06/202</titleOfClass>
			<cusip>G8959N114</cusip>
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			<shrsOrPrnAmt>
				<sshPrnamt>542000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>542000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TOTTENHAM ACQUISITION I LTD</nameOfIssuer>
			<titleOfClass>RIGHT 11/06/2020</titleOfClass>
			<cusip>G8959N122</cusip>
			<value>70</value>
			<shrsOrPrnAmt>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>134000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TRACON PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>89237H209</cusip>
			<value>388</value>
			<shrsOrPrnAmt>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>75000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>TRIDENT ACQUISITIONS CORP</nameOfIssuer>
			<titleOfClass>*W EXP 05/09/202</titleOfClass>
			<cusip>89615T114</cusip>
			<value>734</value>
			<shrsOrPrnAmt>
				<sshPrnamt>1993750</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1993750</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>UNIQURE NV</nameOfIssuer>
			<titleOfClass>SHS</titleOfClass>
			<cusip>N90064101</cusip>
			<value>17679</value>
			<shrsOrPrnAmt>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>480000</Sole>
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				<None>0</None>
			</votingAuthority>
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		<infoTable>
			<nameOfIssuer>US ECOLOGY INC</nameOfIssuer>
			<titleOfClass>*W EXP 10/17/202</titleOfClass>
			<cusip>91734M111</cusip>
			<value>513</value>
			<shrsOrPrnAmt>
				<sshPrnamt>105350</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>105350</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>VENTAS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>92276F100</cusip>
			<value>6294</value>
			<shrsOrPrnAmt>
				<sshPrnamt>150000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Call</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>150000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>VENTAS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>92276F100</cusip>
			<value>6294</value>
			<shrsOrPrnAmt>
				<sshPrnamt>150000</sshPrnamt>
				<sshPrnamtType>SH</sshPrnamtType>
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			<putCall>Put</putCall>
			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>150000</Sole>
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		<infoTable>
			<nameOfIssuer>VYNE THERAPEUTICS INC</nameOfIssuer>
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			<value>9909</value>
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			<investmentDiscretion>DFND</investmentDiscretion>
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		<infoTable>
			<nameOfIssuer>WARRIOR MET COAL INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>93627C101</cusip>
			<value>3758</value>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>220000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>WELLS FARGO CO NEW</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>949746101</cusip>
			<value>23510</value>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>1000000</Sole>
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		<infoTable>
			<nameOfIssuer>WORLD ACCEP CORP DEL</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>981419104</cusip>
			<value>1942</value>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>XERIS PHARMACEUTICALS INC</nameOfIssuer>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>7500000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>XERIS PHARMACEUTICALS INC</nameOfIssuer>
			<titleOfClass>COM</titleOfClass>
			<cusip>98422L107</cusip>
			<value>1385</value>
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				<sshPrnamt>233600</sshPrnamt>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>233600</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>ZILLOW GROUP INC</nameOfIssuer>
			<titleOfClass>CL A</titleOfClass>
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			<value>9139</value>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>90000</Sole>
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				<None>0</None>
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		<infoTable>
			<nameOfIssuer>ZOGENIX INC</nameOfIssuer>
			<titleOfClass>COM NEW</titleOfClass>
			<cusip>98978L204</cusip>
			<value>2062</value>
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				<sshPrnamtType>SH</sshPrnamtType>
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			<investmentDiscretion>DFND</investmentDiscretion>
			<votingAuthority>
				<Sole>115000</Sole>
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				<None>0</None>
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</informationTable>
