ABEONA THERAPEUTICS INC COM NEW 00289Y206 BBG001S8T7K0 4065600 770000 SH DFND 1 770000 0 0 ALDEYRA THERAPEUTICS INC COM 01438T106 BBG0029H8ZG5 4280400 820000 SH DFND 1 820000 0 0 ALECTOR INC COM 014442107 BBG00N0PL214 2960000 1000000 SH DFND 1 1000000 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 BBG001S7FTC8 61879200 135700 SH Put DFND 1 135700 0 0 ALPHABET INC CAP STK CL A 02079K305 BBG009S39JY5 8751600 36000 SH DFND 1 36000 0 0 AMAZON COM INC COM 023135106 BBG001S5PQL7 5818605 26500 SH DFND 1 26500 0 0 AMENTUM HOLDINGS INC COM 023939101 BBG01NY7B770 30536250 1275000 SH DFND 1 1275000 0 0 AMICUS THERAPEUTICS INC COM 03152W109 BBG001SN96V9 6579800 835000 SH DFND 1 835000 0 0 AMRIZE LTD SHS H2927K103 BBG01T2JZYW3 1698550 35000 SH DFND 1 35000 0 0 AMYLYX PHARMACEUTICALS INC COM 03237H101 BBG00DP10YW1 23918400 1760000 SH DFND 1 1760000 0 0 ANAPTYSBIO INC COM 032724106 BBG0026ZDHT8 16749140 547000 SH DFND 1 547000 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 BBG007KGRPZ3 6517440 288000 SH DFND 1 288000 0 0 APOLLOMICS INC *W EXP 04/01/202 G0411D115 2483 130000 SH DFND 1 130000 0 0 ARIS MNG CORP COM 04040Y109 BBG001S75835 8818015 900000 SH DFND 1 900000 0 0 ARK ETF TR INNOVATION ETF 00214Q104 BBG007FJMV49 3236250 37500 SH Put DFND 1 37500 0 0 ASML HOLDING N V N Y REGISTRY SHS N07059210 BBG001SCG0R3 10648991 11000 SH DFND 1 11000 0 0 BARNES & NOBLE ED INC COM NEW 06777U200 BBG009CNQCX5 3482500 350000 SH DFND 1 350000 0 0 BARRICK MNG CORP COM SHS 06849F108 BBG001S5N9P3 24577500 750000 SH DFND 1 750000 0 0 BLUE WTR ACQUISITION CORP. I *W EXP 05/23/203 G1368E114 10643 75000 SH DFND 1 75000 0 0 BLUE WTR ACQUISITION CORP. I ORD SHS CL A G1368E106 BBG01THFR1T0 1495500 150000 SH DFND 1 150000 0 0 BOREALIS FOODS INC *W EXP 02/07/202 09973D113 15300 200000 SH DFND 1 200000 0 0 BRIDGEBIO PHARMA INC COM 10806X102 BBG00P9KDZL5 15582000 300000 SH DFND 1 300000 0 0 BRIDGEBIO PHARMA INC NOTE 2.500% 3/1 10806XAB8 30445433 21750000 PRN DFND 1 21750000 0 0 BRISTOW GROUP INC COM 11040G103 BBG001YH8QJ6 6324824 175300 SH DFND 1 175300 0 0 BRITISH AMERN TOB PLC SPONSORED ADR 110448107 BBG001S6VV46 2972480 56000 SH DFND 1 56000 0 0 BUILDERS FIRSTSOURCE INC COM 12008R107 BBG001S9CFC7 4365000 36000 SH DFND 1 36000 0 0 CACI INTL INC CL A 127190304 BBG001SF9NK1 5237190 10500 SH DFND 1 10500 0 0 CAE INC COM 124765108 BBG001S5Y4F3 741000 25000 SH DFND 1 25000 0 0 CAESARS ENTERTAINMENT INC NE COM 12769G100 BBG0074Q3NL5 5134750 190000 SH DFND 1 190000 0 0 CAPITAL ONE FINL CORP COM 14040H105 BBG001S65PV8 69088500 325000 SH DFND 1 325000 0 0 CAPITAL ONE FINL CORP COM 14040H105 BBG001S65PV8 15943500 75000 SH Put DFND 1 75000 0 0 CARDLYTICS INC COM 14161W105 BBG00225ZDF8 2855250 1175000 SH DFND 1 1175000 0 0 CARDLYTICS INC NOTE 4.250% 4/0 14161WAD7 7762200 15000000 PRN DFND 1 15000000 0 0 CARTESIAN THERAPEUTICS INC COM NEW 816212302 BBG001V0FQQ0 2350601 230000 SH DFND 1 230000 0 0 CARVANA CO CL A 146869102 BBG00GCTWF71 56586000 150000 SH DFND 1 150000 0 0 CASSAVA SCIENCES INC COM 14817C107 BBG001SCKXX9 1236750 425000 SH DFND 1 425000 0 0 CHENGHE ACQUISITION III CO UNIT 09/09/2030 G2086N113 BBG01VXVZHG2 1996000 200000 SH DFND 1 200000 0 0 COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 BBG001SC5GP2 24927500 650000 SH DFND 1 650000 0 0 COINBASE GLOBAL INC COM CL A 19260Q107 BBG00ZGF7799 1012470 3000 SH DFND 1 3000 0 0 COINBASE GLOBAL INC COM CL A 19260Q107 BBG00ZGF7799 20586890 61000 SH Put DFND 1 61000 0 0 CRESUD S A C I F Y A SPONSORED ADR 226406106 BBG001S7XKP3 4055130 440775 SH DFND 1 440775 0 0 DOUBLEDOWN INTERACTIVE CO LT ADS 25862B109 BBG00V782YP2 2802000 300000 SH DFND 1 300000 0 0 ECARX HOLDINGS INC *W EXP 99/99/999 G29201111 7500 125000 SH DFND 1 125000 0 0 ELEVANCE HEALTH INC FORMERLY COM 036752103 BBG001S6KBQ8 5816160 18000 SH DFND 1 18000 0 0 ELI LILLY & CO COM 532457108 BBG001S5STL8 17358250 22750 SH DFND 1 22750 0 0 ELI LILLY & CO COM 532457108 BBG001S5STL8 114450000 150000 SH Put DFND 1 150000 0 0 EQV VENTURES AC CORP. II *W EXP 06/30/203 G3106Q128 12000 50000 SH DFND 1 50000 0 0 EQV VENTURES AC CORP. II ORD SHS CL A G3106Q102 BBG01VV36CM2 1492500 150000 SH DFND 1 150000 0 0 ERO COPPER CORP COM 296006109 BBG00HNV5D86 12149360 600000 SH DFND 1 600000 0 0 FRACTYL HEALTH INC COM 35168W103 BBG002Y7NH81 7393500 4650000 SH DFND 1 4650000 0 0 GCT SEMICONDUCTOR HLDG INC *W EXP 03/01/202 36170N115 143324 764391 SH DFND 1 764391 0 0 GERON CORP COM 374163103 BBG001S6TSX4 4123700 3010000 SH DFND 1 3010000 0 0 GLOBALSTAR INC COM NEW 378973507 BBG001SPN4X1 4366801 120000 SH DFND 1 120000 0 0 GOSSAMER BIO INC COM 38341P102 BBG00MVWLMC1 13305696 5059200 SH DFND 1 5059200 0 0 GOSSAMER BIO INC COM 38341P102 BBG00MVWLMC1 789263 300100 SH Call DFND 1 300100 0 0 GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 3575775 5145000 PRN DFND 1 5145000 0 0 GXO LOGISTICS INCORPORATED COMMON STOCK 36262G101 BBG00YDGX9Z1 40989750 775000 SH DFND 1 775000 0 0 HARMONY BIOSCIENCES HLDGS IN COM 413197104 BBG00WBPG548 7771920 282000 SH DFND 1 282000 0 0 HILTON GRAND VACATIONS INC COM 43283X105 BBG00CBYY6L2 26131250 625000 SH DFND 1 625000 0 0 HIMS & HERS HEALTH INC COM CL A 433000106 BBG00Q5LQWK9 17583200 310000 SH Put DFND 1 310000 0 0 HOWARD HUGHES HOLDINGS INC COM 44267T102 BBG01HTMDZ63 3122460 38000 SH DFND 1 38000 0 0 HUDSON TECHNOLOGIES INC COM 444144109 BBG001S77CN2 3475500 350000 SH DFND 1 350000 0 0 HYLIION HOLDINGS CORP COMMON STOCK 449109107 BBG00N9MJV02 1625250 825000 SH DFND 1 825000 0 0 IAMGOLD CORP COM 450913108 BBG001S8SMV6 11637000 900000 SH DFND 1 900000 0 0 IMMATICS N.V SHS N44445109 BBG00VTL2J09 4430400 520000 SH DFND 1 520000 0 0 INFLARX NV COM N44821101 BBG00HZ6PLD2 3015000 2250000 SH DFND 1 2250000 0 0 INSMED INC COM PAR $.01 457669307 BBG001S9SKW7 54003750 375000 SH Put DFND 1 375000 0 0 INSPIRED ENTMT INC COM 45782N108 BBG007FJ83T0 10552501 1125000 SH DFND 1 1125000 0 0 INVIVYD INC COM 00534A102 BBG00W4ML048 6930001 6300000 SH DFND 1 6300000 0 0 IONQ INC COM 46222L108 BBG00XZP0LC3 12607500 205000 SH Put DFND 1 205000 0 0 IRSA INVERSIONES Y REP S A SPON GDS ECH 10 450047303 BBG001S8CL18 3956679 334179 SH DFND 1 334179 0 0 ISHARES BITCOIN TRUST ETF SHS BEN INT 46438F101 BBG01KYQ6QS5 2145000 33000 SH DFND 1 33000 0 0 KNOT OFFSHORE PARTNERS LP COM UNITS Y48125101 BBG0046HZ561 12880746 1460402 SH DFND 1 1460402 0 0 LENNAR CORP CL A 526057104 BBG001S5SRK3 9957160 79000 SH DFND 1 79000 0 0 LENNAR CORP CL A 526057104 BBG001S5SRK3 6302000 50000 SH Put DFND 1 50000 0 0 LENNAR CORP CL B 526057302 BBG001SKR1T9 13798850 115000 SH DFND 1 115000 0 0 LEXEO THERAPEUTICS INC COM 52886X107 BBG00YB1C8N4 6126476 922662 SH DFND 1 922662 0 0 LIGHTWAVE ACQUISITION CORP *W EXP 06/06/203 G5490M126 9595 50000 SH DFND 1 50000 0 0 LIGHTWAVE ACQUISITION CORP USD CL A ORD SHS G5490M100 BBG01V8BY866 995000 100000 SH DFND 1 100000 0 0 LULULEMON ATHLETICA INC COM 550021109 BBG001STBM75 4448250 25000 SH Put DFND 1 25000 0 0 MADRIGAL PHARMACEUTICALS INC COM 558868105 BBG001SNKQ42 69716320 152000 SH Put DFND 1 152000 0 0 MASTERBRAND INC COMMON STOCK 57638P104 BBG01B9G4424 2634000 200000 SH DFND 1 200000 0 0 MBX BIOSCIENCES INC COM 55287L101 BBG00W7W53N4 4966500 283800 SH Put DFND 1 283800 0 0 MEDPACE HLDGS INC COM 58506Q109 BBG0065B7K40 10283200 20000 SH Put DFND 1 20000 0 0 MEIRAGTX HLDGS PLC COM G59665102 BBG00KXH4D62 21603749 2625000 SH DFND 1 2625000 0 0 MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 10042500 4875000 SH DFND 1 4875000 0 0 MERSANA THERAPEUTICS INC COM 59045L205 BBG001TZ57P0 776000 100000 SH DFND 1 100000 0 0 MILLROSE PPTYS INC COM CL A 601137102 BBG01RQYH427 2016600 60000 SH DFND 1 60000 0 0 MODULAR MED INC COM NEW 60785L207 BBG001SPX9K3 687276 982103 SH DFND 1 982103 0 0 MOLINA HEALTHCARE INC COM 60855R100 BBG001SKBQ20 15500160 81000 SH DFND 1 81000 0 0 MULTISENSOR AI HOLDINGS INC *W EXP 12/19/202 456948116 5701 150000 SH DFND 1 150000 0 0 NAVIGATOR HLDGS LTD SHS Y62132108 BBG001SRNVY6 2788200 180000 SH DFND 1 180000 0 0 NOBLE CORP PLC ORD SHS A G65431127 BBG018KBK3H7 3619840 128000 SH DFND 1 128000 0 0 NOVO-NORDISK A S ADR 670100205 BBG001S5TSK0 33249608 599200 SH Put DFND 1 599200 0 0 ORIGIN INVT CORP I *W EXP 06/27/203 G67751126 2700 15000 SH DFND 1 15000 0 0 ORIGIN INVT CORP I ORD SHS G67751100 BBG01TW7ZPN5 301500 30000 SH DFND 1 30000 0 0 OYSTER ENTERPRISES II ACQUIS ORD SHS CL A G6861F104 BBG01V67VT73 751650 75000 SH DFND 1 75000 0 0 OYSTER ENTERPRISES II ACQUIS RIGHT 05/22/2030 G6861F138 BBG01V67W0B0 12750 75000 SH DFND 1 75000 0 0 PALANTIR TECHNOLOGIES INC CL A 69608A108 BBG001T53796 206882522 1134100 SH Put DFND 1 1134100 0 0 PANGAEA LOGISTICS SOLUTION L SHS G6891L105 BBG005PTVGJ7 2717800 535000 SH DFND 1 535000 0 0 PATRIA INVESTMENTS LIMITED COM CL A G69451105 BBG00YQ7XKN5 5548000 380000 SH DFND 1 380000 0 0 PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS G70077105 BBG01N0FG7G4 5300000 500000 SH DFND 1 500000 0 0 PHATHOM PHARMACEUTICALS INC COM 71722W107 BBG00P5B2S73 21425873 1820380 SH DFND 1 1820380 0 0 PORCH GROUP INC COM 733245104 BBG00QYZND49 7551000 450000 SH DFND 1 450000 0 0 PROTAGONIST THERAPEUTICS INC COM 74366E102 BBG002B63KP4 27070225 407500 SH DFND 1 407500 0 0 PYXIS ONCOLOGY INC COMMON STOCK 747324101 BBG00PQFFCW4 1165500 525000 SH DFND 1 525000 0 0 SANDISK CORP COM 80004C200 BBG01R388JK6 11893200 106000 SH DFND 1 106000 0 0 SAREPTA THERAPEUTICS INC COM 803607100 BBG001S6KJC6 19077300 990000 SH DFND 1 990000 0 0 SCIENCE APPLICATIONS INTL CO COM 808625107 BBG003BW05L5 5216925 52500 SH DFND 1 52500 0 0 SEADRILL LTD COM G7997W102 BBG015K887C0 6042000 200000 SH DFND 1 200000 0 0 SHATTUCK LABS INC COM 82024L103 BBG00V776CR6 3661996 1532216 SH DFND 1 1532216 0 0 SILVERCORP METALS INC COM 82835P103 BBG001S6YR97 2054000 325000 SH DFND 1 325000 0 0 SPDR GOLD TR GOLD SHS 78463V107 BBG001SCPX28 1777350 5000 SH Call DFND 1 5000 0 0 STAGWELL INC COM CL A 85256A109 BBG00ZV0HW08 5010700 890000 SH DFND 1 890000 0 0 STAR BULK CARRIERS CORP. SHS PAR Y8162K204 BBG001SPYW58 1859000 100000 SH DFND 1 100000 0 0 STRATEGY INC CL A NEW 594972408 BBG001SC7PX1 44658306 138600 SH Put DFND 1 138600 0 0 STRATEGY INC NOTE 0.875% 3/1 594972AL5 7864200 5000000 PRN DFND 1 5000000 0 0 TESLA INC COM 88160R101 BBG001SQKGD7 93613560 210500 SH Put DFND 1 210500 0 0 TG THERAPEUTICS INC COM 88322Q108 BBG001S8NH06 11740625 325000 SH DFND 1 325000 0 0 TRANSMEDICS GROUP INC COM 89377M109 BBG00NZ6J701 2244000 20000 SH Put DFND 1 20000 0 0 TVARDI THERAPEUTICS INC COM 140755307 BBG001V0GHL4 6768424 176030 SH DFND 1 176030 0 0 ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 BBG001V2MJJ2 3188480 106000 SH DFND 1 106000 0 0 UNIQURE NV SHS N90064101 BBG005SSJYG4 62455900 1070000 SH DFND 1 1070000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 BBG001S8RV10 31524592 75200 SH Put DFND 1 75200 0 0 UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 16574400 48000 SH DFND 1 48000 0 0 UWM HOLDINGS CORPORATION COM CL A 91823B109 BBG00R24YP79 45066000 7400000 SH DFND 1 7400000 0 0 VALARIS LTD CL A G9460G101 BBG010JW9K58 1706950 35000 SH DFND 1 35000 0 0 VENTYX BIOSCIENCES INC COM 92332V107 BBG00VC84K47 3110000 1000000 SH DFND 1 1000000 0 0 VIKING THERAPEUTICS INC COM 92686J106 BBG006LGV887 6307200 240000 SH DFND 1 240000 0 0 VIKING THERAPEUTICS INC COM 92686J106 BBG006LGV887 2628000 100000 SH Call DFND 1 100000 0 0 WARRIOR MET COAL INC COM 93627C101 BBG00GD1JNK4 3500200 55000 SH DFND 1 55000 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 BBG00B642V63 30378001 4150000 SH DFND 1 4150000 0 0 WESTERN ALLIANCE BANCORP COM 957638109 BBG001SLM522 8672000 100000 SH DFND 1 100000 0 0 WESTERN DIGITAL CORP COM 958102105 BBG001S5XD28 40700340 339000 SH DFND 1 339000 0 0 WILLOW LANE ACQUISITION CORP *W EXP 10/31/203 G9675P110 238051 85000 SH DFND 1 85000 0 0 WILLOW LANE ACQUISITION CORP ORD SHS CL A G9675P102 BBG01RJQ5283 2316000 200000 SH DFND 1 200000 0 0 XCF GLOBAL INC COM CL A 98400U103 BBG01QM977Y7 54584 41667 SH DFND 1 41667 0 0 XENIA HOTELS & RESORTS INC COM 984017103 BBG006YP1L50 8849400 645000 SH DFND 1 645000 0 0 ZEVRA THERAPEUTICS INC COM NEW 488445206 BBG0026ZG1G4 9272250 975000 SH DFND 1 975000 0 0