<?xml version="1.0" ?>
<proxyVoteTable xmlns="http://www.sec.gov/edgar/document/npxproxy/informationtable">
  <proxyTable>
    <issuerName>Wave Life Sciences Ltd.</issuerName>
    <cusip>Y95308105</cusip>
    <isin>SG9999014716</isin>
    <meetingDate>08/01/2023</meetingDate>
    <voteDescription>To approve, by a non-binding advisory vote, the compensation of our named executive officers as disclosed in the proxy statement</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>6031000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>6031000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>AMC Entertainment Holdings, Inc.</issuerName>
    <cusip>00165C302</cusip>
    <isin>US00165C3025</isin>
    <meetingDate>11/08/2023</meetingDate>
    <voteDescription>Say on Pay - An advisory vote to approve the compensation of named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>5371</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>5371</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Zymeworks Inc.</issuerName>
    <cusip>98985Y108</cusip>
    <isin>US98985Y1082</isin>
    <meetingDate>12/07/2023</meetingDate>
    <voteDescription>Advisory Vote on the compensation of named executive officers</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>64900</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>64900</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Standard BioTools Inc.</issuerName>
    <cusip>34385P108</cusip>
    <isin>US34385P1084</isin>
    <meetingDate>01/04/2024</meetingDate>
    <voteDescription>Standard BioTools Advisory Compensation Proposal. To approve, on a non-binding, advisory basis, the compensation that may become payable to Standard BioTools' named executive officers and to SomaLogic's Chief Executive Officer that is based on or otherwise relates to the Merger, as disclosed in "The Merger - Interests of Standard BioTools Directors and Executive Officers in the Merger - Quantification of Potential Payments to Standard BioTools Named Executive Officers and SomaLogic's Chief Executive Officer in Connection with the Merger" beginning on page 127 of the accompanying joint proxy statement/prospectus (the "Standard BioTools Advisory Compensation Proposal");</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>5271</sharesVoted>
    <sharesOnLoan>17003</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5271</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Geospace Technologies Corporation</issuerName>
    <cusip>37364X109</cusip>
    <isin>US37364X1090</isin>
    <meetingDate>02/08/2024</meetingDate>
    <voteDescription>To approve the following non-binding, advisory resolution: ''RESOLVED, that the stockholders approve the compensation of the Company's named executive officers as disclosed in the Company's 2024 proxy statement pursuant to Item 402 of Regulation S-K, (which disclosure includes the Overview of the Company Executive Compensation Program, the Summary Compensation Table and the other executive compensation tables and related discussion).''</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>18261</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>18261</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>FingerMotion, Inc.</issuerName>
    <cusip>31788K108</cusip>
    <isin>US31788K1088</isin>
    <meetingDate>02/16/2024</meetingDate>
    <voteDescription>To approve, on a non-binding advisory basis, the compensation of the named executive officers, as more particularly described in the Schedule 14A - Proxy Statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>0</sharesVoted>
    <sharesOnLoan>51393</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>DID NOT VOTE</howVoted>
        <sharesVoted>0</sharesVoted>
        <managementRecommendation>NONE</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Bassett Furniture Industries, Incorporated</issuerName>
    <cusip>070203104</cusip>
    <isin>US0702031040</isin>
    <meetingDate>03/06/2024</meetingDate>
    <voteDescription>PROPOSAL to consider and act on an advisory vote regarding the approval of compensation paid to certain executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>9512</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>9512</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>DLH Holdings Corp.</issuerName>
    <cusip>23335Q100</cusip>
    <isin>US23335Q1004</isin>
    <meetingDate>03/14/2024</meetingDate>
    <voteDescription>An Advisory Vote regarding the approval of compensation paid to our named Executive Officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>7998</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>7998</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Lennar Corporation</issuerName>
    <cusip>526057302</cusip>
    <isin>US5260573028</isin>
    <meetingDate>04/10/2024</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>138677</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>138677</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Rekor Systems, Inc.</issuerName>
    <cusip>759419104</cusip>
    <isin>US7594191048</isin>
    <meetingDate>04/18/2024</meetingDate>
    <voteDescription>Advisory vote to approve the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>5998</sharesVoted>
    <sharesOnLoan>32538</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>5998</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Franklin Financial Services Corporation</issuerName>
    <cusip>353525108</cusip>
    <isin>US3535251082</isin>
    <meetingDate>04/23/2024</meetingDate>
    <voteDescription>Say on Pay - Executive Compensation</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>500</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>500</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BorgWarner Inc.</issuerName>
    <cusip>099724106</cusip>
    <isin>US0997241064</isin>
    <meetingDate>04/24/2024</meetingDate>
    <voteDescription>Approve, on an advisory basis, the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1165971</sharesVoted>
    <sharesOnLoan>134029</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1165971</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Citigroup Inc.</issuerName>
    <cusip>172967424</cusip>
    <isin>US1729674242</isin>
    <meetingDate>04/30/2024</meetingDate>
    <voteDescription>Advisory vote to Approve our 2023 Executive Compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>300000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>300000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Capital One Financial Corporation</issuerName>
    <cusip>14040H105</cusip>
    <isin>US14040H1059</isin>
    <meetingDate>05/02/2024</meetingDate>
    <voteDescription>Advisory vote on our Named Executive Officer compensation ("Say on Pay").</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>335000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>335000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ryder System, Inc.</issuerName>
    <cusip>783549108</cusip>
    <isin>US7835491082</isin>
    <meetingDate>05/03/2024</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>194940</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>194940</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Carvana Co.</issuerName>
    <cusip>146869102</cusip>
    <isin>US1468691027</isin>
    <meetingDate>05/06/2024</meetingDate>
    <voteDescription>Approval, by an advisory vote, of Carvana's executive compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>324833</sharesVoted>
    <sharesOnLoan>20167</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>324833</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Cogent Communications Holdings, Inc.</issuerName>
    <cusip>19239V302</cusip>
    <isin>US19239V3024</isin>
    <meetingDate>05/08/2024</meetingDate>
    <voteDescription>PROPOSAL - Non-binding Advisory Vote to Approve Named Executive Officer Compensation;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>187134</sharesVoted>
    <sharesOnLoan>7866</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>187134</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Enova International, Inc.</issuerName>
    <cusip>29357K103</cusip>
    <isin>US29357K1034</isin>
    <meetingDate>05/08/2024</meetingDate>
    <voteDescription>A non-binding advisory vote to approve the compensation paid to the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>250000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>250000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Hilton Grand Vacations Inc.</issuerName>
    <cusip>43283X105</cusip>
    <isin>US43283X1054</isin>
    <meetingDate>05/08/2024</meetingDate>
    <voteDescription>Approve by non-binding vote the compensation paid to the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1194508</sharesVoted>
    <sharesOnLoan>5492</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1194508</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Discover Financial Services</issuerName>
    <cusip>254709108</cusip>
    <isin>US2547091080</isin>
    <meetingDate>05/09/2024</meetingDate>
    <voteDescription>Advisory vote to approve named executive officer compensation:</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>20000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>20000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Zevra Therapeutics, Inc.</issuerName>
    <cusip>488445206</cusip>
    <isin>US4884452065</isin>
    <meetingDate>05/13/2024</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy materials</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>779179</sharesVoted>
    <sharesOnLoan>20821</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>779179</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>QuidelOrtho Corporation</issuerName>
    <cusip>219798105</cusip>
    <isin>US2197981051</isin>
    <meetingDate>05/14/2024</meetingDate>
    <voteDescription>Approval of, on an advisory basis, the compensation of QuidelOrtho's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>129919</sharesVoted>
    <sharesOnLoan>81</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>129919</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Xenia Hotels &amp; Resorts, Inc.</issuerName>
    <cusip>984017103</cusip>
    <isin>US9840171030</isin>
    <meetingDate>05/14/2024</meetingDate>
    <voteDescription>To approve, on an advisory and non-binding basis, the compensation of the named executive officers as disclosed in the proxy statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1470097</sharesVoted>
    <sharesOnLoan>4903</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1470097</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>RXO, Inc.</issuerName>
    <cusip>74982T103</cusip>
    <isin>US74982T1034</isin>
    <meetingDate>05/20/2024</meetingDate>
    <voteDescription>Advisory Vote to Approve Executive Compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>448177</sharesVoted>
    <sharesOnLoan>51823</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>448177</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Noble Corporation plc</issuerName>
    <cusip>G65431127</cusip>
    <isin>GB00BMXNWH07</isin>
    <meetingDate>05/21/2024</meetingDate>
    <voteDescription>Approval of the Company's Executive Compensation</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>73209</sharesVoted>
    <sharesOnLoan>74983</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>73209</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Viking Therapeutics, Inc.</issuerName>
    <cusip>92686J106</cusip>
    <isin>US92686J1060</isin>
    <meetingDate>05/21/2024</meetingDate>
    <voteDescription>TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>356376</sharesVoted>
    <sharesOnLoan>3624</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>356376</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Cardlytics, Inc.</issuerName>
    <cusip>14161W105</cusip>
    <isin>US14161W1053</isin>
    <meetingDate>05/23/2024</meetingDate>
    <voteDescription>Advisory vote to approve compensation of named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1844354</sharesVoted>
    <sharesOnLoan>155546</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>1844354</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Apellis Pharmaceuticals, Inc.</issuerName>
    <cusip>03753U106</cusip>
    <isin>US03753U1060</isin>
    <meetingDate>06/05/2024</meetingDate>
    <voteDescription>Approval of an advisory vote on executive compensation; and</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>181472</sharesVoted>
    <sharesOnLoan>33528</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>181472</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>FibroGen, Inc.</issuerName>
    <cusip>31572Q808</cusip>
    <isin>US31572Q8087</isin>
    <meetingDate>06/05/2024</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1660214</sharesVoted>
    <sharesOnLoan>189786</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1660214</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>FibroGen, Inc.</issuerName>
    <cusip>31572Q808</cusip>
    <isin>US31572Q8087</isin>
    <meetingDate>06/05/2024</meetingDate>
    <voteDescription>To indicate, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1660214</sharesVoted>
    <sharesOnLoan>189786</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>1660214</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Gossamer Bio, Inc.</issuerName>
    <cusip>38341P102</cusip>
    <isin>US38341P1021</isin>
    <meetingDate>06/06/2024</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of the Company's named executive officers as disclosed in the proxy statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>3300000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>3300000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>MeiraGTx Holdings Plc</issuerName>
    <cusip>G59665102</cusip>
    <isin>KYG596651029</isin>
    <meetingDate>06/06/2024</meetingDate>
    <voteDescription>To approve, on an advisory (non-binding) basis, the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>2474865</sharesVoted>
    <sharesOnLoan>25135</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>2474865</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>MeiraGTx Holdings Plc</issuerName>
    <cusip>G59665102</cusip>
    <isin>KYG596651029</isin>
    <meetingDate>06/06/2024</meetingDate>
    <voteDescription>To approve, on an advisory (non-binding) basis, the frequency of future advisory votes on the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>2474865</sharesVoted>
    <sharesOnLoan>25135</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>2474865</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Sarepta Therapeutics, Inc.</issuerName>
    <cusip>803607100</cusip>
    <isin>US8036071004</isin>
    <meetingDate>06/06/2024</meetingDate>
    <voteDescription>advisory vote to approve, on a non-binding basis, name executive officer compensation</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>60479</sharesVoted>
    <sharesOnLoan>2350</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>60479</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>SAGE Therapeutics, Inc.</issuerName>
    <cusip>78667J108</cusip>
    <isin>US78667J1088</isin>
    <meetingDate>06/10/2024</meetingDate>
    <voteDescription>To hold a non-binding advisory vote to approve the compensation paid to our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>205976</sharesVoted>
    <sharesOnLoan>69024</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>205976</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Aadi Bioscience, Inc.</issuerName>
    <cusip>00032Q104</cusip>
    <isin>US00032Q1040</isin>
    <meetingDate>06/11/2024</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of the named executive officers identified in the 2023 Summary Compensation Table in the "Executive Compensation" section of the proxy statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>200000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>200000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Caesars Entertainment, Inc.</issuerName>
    <cusip>12769G100</cusip>
    <isin>US12769G1004</isin>
    <meetingDate>06/11/2024</meetingDate>
    <voteDescription>COMPANY PROPOSAL: ADVISORY VOTE TO APPROVE NAMED EXECUTIVE OFFICER COMPENSATION.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>269560</sharesVoted>
    <sharesOnLoan>75440</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>269560</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Iovance Biotherapeutics, Inc.</issuerName>
    <cusip>462260100</cusip>
    <isin>US4622601007</isin>
    <meetingDate>06/11/2024</meetingDate>
    <voteDescription>To approve, by non-binding advisory vote, the compensation of our named executive officers;</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>737178</sharesVoted>
    <sharesOnLoan>487822</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>737178</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>LendingClub Corporation</issuerName>
    <cusip>52603A208</cusip>
    <isin>US52603A2087</isin>
    <meetingDate>06/11/2024</meetingDate>
    <voteDescription>Approve, on a non-binding advisory basis, the compensation of our named executive officers as disclosed in the Proxy Statement.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>201400</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>201400</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Valaris Limited</issuerName>
    <cusip>G9460G101</cusip>
    <isin>BMG9460G1015</isin>
    <meetingDate>06/12/2024</meetingDate>
    <voteDescription>To approve on a non-binding advisory basis the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>133511</sharesVoted>
    <sharesOnLoan>59646</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>133511</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Western Alliance Bancorporation</issuerName>
    <cusip>957638109</cusip>
    <isin>US9576381092</isin>
    <meetingDate>06/12/2024</meetingDate>
    <voteDescription>Approve, on a non-binding advisory basis, executive compensation (say on pay).</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>200000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>200000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Western Alliance Bancorporation</issuerName>
    <cusip>957638109</cusip>
    <isin>US9576381092</isin>
    <meetingDate>06/12/2024</meetingDate>
    <voteDescription>Approve, on a non-binding advisory basis, frequency of the non-binding vote on executive compensation (say on frequency).</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>200000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>ONE YEAR</howVoted>
        <sharesVoted>200000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Etsy, Inc.</issuerName>
    <cusip>29786A106</cusip>
    <isin>US29786A1060</isin>
    <meetingDate>06/13/2024</meetingDate>
    <voteDescription>Advisory vote to approve named executive officer compensation.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>110000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>110000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Ponce Financial Group, Inc.</issuerName>
    <cusip>732344106</cusip>
    <isin>US7323441060</isin>
    <meetingDate>06/13/2024</meetingDate>
    <voteDescription>Approval, on an advisory and non-binding basis, of the compensation of the named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>94877</sharesVoted>
    <sharesOnLoan>11260</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>94877</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Tesla, Inc.</issuerName>
    <cusip>88160R101</cusip>
    <isin>US88160R1014</isin>
    <meetingDate>06/13/2024</meetingDate>
    <voteDescription>A Tesla proposal to approve executive compensation on a non-binding advisory basis.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>46500</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>46500</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Aurinia Pharmaceuticals Inc.</issuerName>
    <cusip>05156V102</cusip>
    <isin>CA05156V1022</isin>
    <meetingDate>06/14/2024</meetingDate>
    <voteDescription>Advisory Resolution on Executive Compensation To approve, on a non-binding advisory basis, a "say on pay" resolution regarding the Company's executive compensation set forth in the Company's Proxy Statement/Circular.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>585000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>585000</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>TG Therapeutics, Inc.</issuerName>
    <cusip>88322Q108</cusip>
    <isin>US88322Q1085</isin>
    <meetingDate>06/14/2024</meetingDate>
    <voteDescription>An advisory vote to approve the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>785658</sharesVoted>
    <sharesOnLoan>593496</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>AGAINST</howVoted>
        <sharesVoted>785658</sharesVoted>
        <managementRecommendation>AGAINST</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>uniQure N.V.</issuerName>
    <cusip>N90064101</cusip>
    <isin>NL0010696654</isin>
    <meetingDate>06/18/2024</meetingDate>
    <voteDescription>Approval, on an advisory basis, of the compensation of the named executive officers of the Company.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>1975000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>1975000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>Protagonist Therapeutics, Inc.</issuerName>
    <cusip>74366E102</cusip>
    <isin>US74366E1029</isin>
    <meetingDate>06/20/2024</meetingDate>
    <voteDescription>To approve, on an advisory basis, the compensation of our named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>700000</sharesVoted>
    <sharesOnLoan>0</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>700000</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
  <proxyTable>
    <issuerName>BridgeBio Pharma, Inc.</issuerName>
    <cusip>10806X102</cusip>
    <isin>US10806X1028</isin>
    <meetingDate>06/21/2024</meetingDate>
    <voteDescription>To cast a non-binding, advisory vote to approve the compensation of the Company's named executive officers.</voteDescription>
    <voteCategories>
      <voteCategory>
        <categoryType>SECTION 14A SAY-ON-PAY VOTES</categoryType>
      </voteCategory>
    </voteCategories>
    <sharesVoted>101328</sharesVoted>
    <sharesOnLoan>18672</sharesOnLoan>
    <vote>
      <voteRecord>
        <howVoted>FOR</howVoted>
        <sharesVoted>101328</sharesVoted>
        <managementRecommendation>FOR</managementRecommendation>
      </voteRecord>
    </vote>
  </proxyTable>
</proxyVoteTable>
