Exhibit 28

SIXTH AMENDED AND RESTATED JOINT FILING AGREEMENT

This Sixth Amended and Restated Joint Filing Agreement (this “Agreement”) amends and restates the Fifth Amended and Restated Joint Filing Agreement, dated January 21, 2021.

Pursuant to and in accordance with the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder (the “Exchange Act”) the undersigned hereby agree to the joint filing on behalf of each of them of any filing required by such party under Section 13 of the Exchange Act or any rule or regulation thereunder (including any amendment, restatement, supplement, and/or exhibit thereto) with respect to securities of Lexicon Pharmaceuticals, Inc., a Delaware corporation, and further agree to the filing, furnishing, and/or incorporation by reference of this Agreement as an exhibit thereto. Each of them is responsible for the timely filing of each such filings and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such information is inaccurate. This Agreement shall remain in full force and effect until revoked by any party hereto in a signed writing provided to each other party hereto, and then only with respect to such revoking party. This Agreement may be executed in any number of counterparts all of which taken together shall constitute one and the same instrument.

Dated: July 29, 2024

INVUS, L.P.
By: INVUS ADVISORS, L.L.C., its general partner
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
INVUS PUBLIC EQUITIES, L.P.
By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
INVUS ADVISORS, L.L.C.
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
INVUS PUBLIC EQUITIES ADVISORS, LLC
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President

INVUS GLOBAL MANAGEMENT, LLC
By:	/s/ Raymond Debbane
Name: Raymond Debbane
Title: President
SIREN, L.L.C.
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
ARTAL INTERNATIONAL S.C.A.
By: Artal International Management S.A., its managing partner
By:	/s/ Pierre Claudel
Name:	Pierre Claudel
Title:	Managing Director
ARTAL INTERNATIONAL MANAGEMENT S.A.
By:	/s/ Pierre Claudel
Name:	Pierre Claudel
Title:	Managing Director
ARTAL GROUP S.A.
By:	/s/ Anne Goffard
Name:	Anne Goffard
Title:	Authorized Person
WESTEND S.A.
By:	/s/ Pierre Claudel
Name:	Pierre Claudel
Title:	Managing Director
STICHTING ADMINISTRATIEKANTOOR WESTEND
By:	/s/ Amaury Wittouck
Name:	Amaury Wittouck
Title:	Sole Member of the Board
AMAURY WITTOUCK
By:	/s/ Amaury Wittouck

INVUS US PARTNERS LLC
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
ULYS, L.L.C.
By:	/s/ Raymond Debbane
Name:	Raymond Debbane
Title:	President
RAYMOND DEBBANE
By:	/s/ Raymond Debbane

SCHEDULE I

The name, citizenship and present principal occupation or employment of each executive officer of Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC, Invus US Partners LLC, Invus Global Management, LLC, Siren, L.L.C. and Ulys, L.L.C. are set forth below. The business address for each of the persons listed below and the address of the principal executive offices of each of The Invus Group, LLC, Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC, Invus US Partners LLC, Invus Global Management, LLC, Siren, L.L.C. and Ulys, L.L.C. is 750 Lexington Avenue, 30th Floor, New York, NY 10022. The Invus Group, LLC is a private equity and investment management firm. See Item 2 of this Statement for a description of the principal business of each of Invus Advisors, L.L.C., Invus Public Equities Advisors, LLC, Invus US Partners LLC, Invus Global Management, LLC, Siren, L.L.C. and Ulys, L.L.C.

NAME	PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT	CITIZENSHIP
Invus Advisors, L.L.C.
Raymond Debbane, President and Chief Executive Officer	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama
Christopher Sobecki, Managing Director	Managing Director of The Invus Group, LLC	United States
Philippe Amouyal, Managing Director	Managing Director of The Invus Group, LLC	United States
Jonas Fajgenbaum, Managing Director	Managing Director of The Invus Group, LLC	United States
Aflalo Guimarães, Managing Director	Managing Director of The Invus Group, LLC	United States
Evren Bilimer, Managing Director	Managing Director of The Invus Group, LLC	United States
Benjamin Felt, Managing Director	Chief Operating Officer (Private Equity) of The Invus Group, LLC	United States
Philip Bafundo, Chief Financial Officer, Chief Compliance Officer, Treasurer and Secretary	Chief Financial Officer and Chief Compliance Officer of The Invus Group, LLC	United States
Invus Public Equities Advisors, LLC
Raymond Debbane, President and Chief Executive Officer	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama
Khalil Barrage, Vice President	Managing Director of The Invus Group, LLC	United States
Christopher Sobecki, Vice President	Managing Director of The Invus Group, LLC	United States
Philip Bafundo, Chief Financial Officer, Chief Compliance Officer, Treasurer and Secretary	Chief Financial Officer and Chief Compliance Officer of The Invus Group, LLC	United States

NAME	PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT	CITIZENSHIP
Ulys, L.L.C.
Raymond Debbane, President, Treasurer and Secretary	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama

NAME	PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT	CITIZENSHIP
Invus US Partners LLC
Raymond Debbane, President and Secretary	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama

NAME	PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT	CITIZENSHIP
Invus Global Management, LLC
Raymond Debbane, President, Treasurer and Secretary	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama
Philip Bafundo, Chief Financial Officer and Treasurer	Chief Financial Officer and Chief Compliance Officer of The Invus Group, LLC	United States
David Van Zandt, Secretary	Global General Counsel and Secretary of The Invus Group, LLC	United States

NAME	PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT	CITIZENSHIP
Siren, L.L.C.
Raymond Debbane, President, Treasurer and Secretary	President and Chief Executive Officer of The Invus Group, LLC, Chief Executive Officer of Artal Group S.A., Chairman of the board of directors of the Issuer	Panama