X0306 4 2020-03-19 0 0001404281 Novus Therapeutics, Inc. NVUS 0001664784 Kuwahara Jon C/O NOVUS THERAPEUTICS, INC. 19900 MACARTHUR BLVD., SUITE 550 IRVINE CA 92612 0 1 0 0 See Remarks Stock Option (Right to Buy) 0.26 2020-03-19 4 A 0 50000 0.00 A 2030-03-19 Common Stock 50000 50000 D This option represents a right to purchase a total of 50,000 shares of the Issuer's Common Stock, one quarter of which will become fully vested and exercisable on March 19, 2021, with the remaining 37,500 shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. Senior Vice President of Finance and Administration /s/ Ryan A. Murr, as attorney-in-fact for Jon Kuwahara 2020-03-20